Cardiac Volume Receptor Reflex in Borderline Hypertensive Rats

With increased dietary NaCl intake (8% NaCl), borderline hypertensive rats (BHR) develop hypertension and exhibit an exaggerated natriuresis in response to intravenous isotonic saline volume expansion. The exaggerated natriuresis is mediated by the concurrent exaggerated withdrawal of efferent renal...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1993-02, Vol.21 (2), p.222-226
Main Authors: Di Bona, Gerald F, Jones, Susan Y
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Volume - drug effects
Blood Volume - physiology
Cardiology. Vascular system
Denervation
Electric Stimulation
Experimental diseases
Heart - physiopathology
Hypertension - genetics
Hypertension - physiopathology
Kidney - innervation
Male
Medical sciences
Mice
Osmolar Concentration
Rats
Rats, Mutant Strains
Sinus of Valsalva - innervation
Sodium Chloride - pharmacology
Sympathetic Nervous System - physiology
Vagus Nerve - physiology
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Summary:With increased dietary NaCl intake (8% NaCl), borderline hypertensive rats (BHR) develop hypertension and exhibit an exaggerated natriuresis in response to intravenous isotonic saline volume expansion. The exaggerated natriuresis is mediated by the concurrent exaggerated withdrawal of efferent renal sympathetic nerve activity since prior renal denervation eliminates the exaggerated natriuretic response. It was the objective of the present study to examine cardiac volume receptor reflex control of efferent renal sympathetic nerve activity in BHR made hypertensive by increased dietary NaCl intake. BHR were fed either 1% or 8% NaCl from age 4 to 16 weeks. BHR fed 8% NaCl were hypertensive (148±9 mm Hg) compared with BHR fed 1% NaCl (115±6 mm Hg, p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.21.2.222