Altered Blood Pressure During Sleep in Normotensive Subjects With Type I Diabetes

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 1993-02, Vol.21 (2), p.227-235
• Main Authors: Lurbe, Ampar, Redón, Josep, Pascual, Jose M, Tacons, Jose, Alvarez, Vicente, Batlle, Daniel C
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Albuminuria - etiology; Biological and medical sciences; Blood Pressure; Child; Circadian Rhythm; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 1 - urine; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Male; Medical sciences; Reference Values; Sleep - physiology
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/01.HYP.21.2.227

This study was designed to examine the circadian pattern of blood pressure in children and young adults with type I diabetes who were completely normotensive by standard criteria. Forty-five patients and the same number of age- and sex-matched control subjects were studied. In diabetic children of 10–14 years of age, the nocturnal fall in systolic and diastolic blood pressures was intact. In diabetics of 15–20 years of age, the fall in systolic blood pressure was blunted; in diabetics of 21–37 years of age, the fall in both systolic and diastolic blood pressures during sleep was blunted. When data from all diabetic subjects were pooled and analyzed in a multiple linear regression model, mean blood pressure during sleep correlated best with urinary albumin excretion (r=0.60). On the basis of this finding, we subdivided our patients into two groupsa microalbuminuric group (urinary albumin excretion >30 mg per 24 hours; mean, 160.3±29.7; n=11) and a normoalbuminuric group (urinary albumin excretion