Bone healing after bone marrow stromal cell transplantation to the bone defect

In experimental studies on rabbits, osteogenic properties of stromal cells were confirmed after in vitro growth for 7 and 14 d. The cell suspension was percutaneously transplanted into a surgically produced bone defect in the rabbit's radius. The bone scar produced was X-rayed, and histological...

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Bibliographic Details
Published in:Biomaterials 1993, Vol.14 (2), p.115-121
Main Authors: Niedźwiedzki, Tadeusz, Dabrowski, Zbigniew, Miszta, Helena, Pawlikowski, Maciej
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone Density - physiology
Bone Marrow Cells
Bone Marrow Transplantation
Cell Division - physiology
cell transplantation
fracture healing
Fracture Healing - physiology
Male
Medical sciences
Microscopy, Electron
Orthopedic surgery
Osteogenesis
Rabbits
Radius - surgery
Radius - ultrastructure
Stromal Cells - transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:In experimental studies on rabbits, osteogenic properties of stromal cells were confirmed after in vitro growth for 7 and 14 d. The cell suspension was percutaneously transplanted into a surgically produced bone defect in the rabbit's radius. The bone scar produced was X-rayed, and histologically and mineralogically examined after 10, 20 and 40 d follow-ups. Differences in the bone defect healing process (the healing rate and the type of bone tissue produced) were shown between the experimental and the control foreleg. Within the experimental foreleg, healing was considerably accelerated with compact bone formation on a membranous matrix, whilst in the control foreleg, a coarse, fibrous woven bone on a cartilaginous matrix was dominant.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(93)90221-M