BIPHENOMYCIN C, A PRECURSOR OF BIPHENOMYCIN A IN MIXED CULTURE

A precursor of biphenomycin A in mixed culture of Streptomyces griseorubiginosus No. 43708 with Pseudomonas maltophilia No. 1928 was isolated and characterized. The structure of the precursor, designated biphenomycin C was determined to be a peptide which is composed of biphenomycin A and arginylser...

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Bibliographic Details
Published in:Journal of antibiotics 1993/01/25, Vol.46(1), pp.135-140
Main Authors: EZAKI, MASAMI, SHIGEMATSU, NOBUHARU, YAMASHITA, MICHIO, KOMORI, TADAAKI, UMEHARA, KAZUYOSHI, IMANAKA, HIROSHI
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Biotransformation
Biphenyl Compounds - chemistry
Biphenyl Compounds - isolation & purification
Biphenyl Compounds - pharmacology
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dipeptides - metabolism
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-Positive Bacteria - drug effects
Magnetic Resonance Spectroscopy
Microbiology
Peptides
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Prodrugs - chemistry
Prodrugs - isolation & purification
Prodrugs - pharmacology
Pseudomonas - metabolism
Streptococcus - metabolism
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Summary:A precursor of biphenomycin A in mixed culture of Streptomyces griseorubiginosus No. 43708 with Pseudomonas maltophilia No. 1928 was isolated and characterized. The structure of the precursor, designated biphenomycin C was determined to be a peptide which is composed of biphenomycin A and arginylserine residue (Fig. 1), on the basis of chemical and spectroscopic evidence.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.135