Magnetic resonance imaging of the brain in Wilson's disease

Fifteen patients with Wilson's disease were examined, using spin-echo (SE) and gradient-echo (GE) sequences with 0.5 T and 1.5 T magnetic resonance (MR) imagers. They fell into three groups: groups 1 and 2 were examined retrospectively after 3-18 years of treatment, while group 3 was examined p...

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Bibliographic Details
Published in:Neuroradiology 1993-01, Vol.35 (2), p.134-141
Main Authors: THUOMAS, K. Å, AQUILONIUS, S. M, BERGSTRÖM, K, WESTERMARK, K
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - pathology
Hepatolenticular Degeneration - diagnosis
Hepatolenticular Degeneration - drug therapy
Hepatolenticular Degeneration - pathology
Humans
Magnetic Resonance Imaging
Medical sciences
Metabolic diseases
Metals (hemochromatosis...)
Middle Aged
Other metabolic disorders
Prospective Studies
Retrospective Studies
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Summary:Fifteen patients with Wilson's disease were examined, using spin-echo (SE) and gradient-echo (GE) sequences with 0.5 T and 1.5 T magnetic resonance (MR) imagers. They fell into three groups: groups 1 and 2 were examined retrospectively after 3-18 years of treatment, while group 3 was examined prospectively from the start of treatment, after recommencement of treatment, or inadequate treatment. MRI was sensitive to changes in the basal ganglia at sites typical of Wilson's disease and was useful for documenting the effects of treatment. It was found necessary to estimate the relaxation times T1 and T2, to better assess improvement or transient worsening of the disease in the prospective group. Residual cavitation and gliosis could be distinguished in the retrospective group using a subtraction technique.
ISSN:0028-3940
1432-1920
DOI:10.1007/BF00593970