Epigrisorixin, a new polyether carboxylic antibiotic

Grisorixin (1) belongs to the group of carboxylic polyether antibiotics. Some of them are used as feed additives acting as anticoccidial agents and growth promoters in ruminants. The biosynthesis of this antibiotic family has attracted a great deal of interest. In the course of our study on the bios...

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Bibliographic Details
Published in:Journal of antibiotics 1993, Vol.46 (1), p.201-203
Main Authors: MOUSLIM, J, CUER, A, DAVID, L, TABET, J. C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacillus cereus - drug effects
Biological and medical sciences
Biotransformation
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Microbiology
Nigericin - analogs & derivatives
Nigericin - biosynthesis
Nigericin - isolation & purification
Nigericin - metabolism
Nigericin - pharmacology
Streptococcus - metabolism
Streptomyces hygroscopicus
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Summary:Grisorixin (1) belongs to the group of carboxylic polyether antibiotics. Some of them are used as feed additives acting as anticoccidial agents and growth promoters in ruminants. The biosynthesis of this antibiotic family has attracted a great deal of interest. In the course of our study on the biosynthesis of the carboxylic polyether antibiotic, nigericin (2), produced by Streptomyces hygroscopicus NRRL B-1865, the addition to methyl oleate (1%) to the original fermentation culture increased the antibiotic titer. Under these conditions, three nigericin-type antibiotics were isolated, grisorixin (1) (unpublished data), abierixin and epinigericin (3). The comparative biological activity of the two epimeric antibiotics, nigericin and epinigericin on a protist Tetrahymena pyriformis GL and Bacillus cereus showed that epinigericin was less toxic than nigericin. The present paper describes the ability of the microorganism S. hygroscopicus NRRL B-1865 to biotransform grisorixin to epigrisorixin (4) which may be also less toxic and the isolation and identification of the bioconversion product.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.201