The haemodynamic effects and pharmacokinetics of intravenous nicorandil in healthy volunteers

• Published in: European journal of clinical pharmacology 1993, Vol.44 (1), p.27-33
• Main Authors: WOLF, D. L, FERRY, J, HEARRON, A. E, FROESCHKE, M. O, LUDERER, J. R
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antianginal agents. Coronary vasodilator agents; Biological and medical sciences; Blood Pressure - drug effects; Cardiovascular system; Electrocardiography - drug effects; Female; Heart Rate - drug effects; Hemodynamics - drug effects; Humans; Infusions, Intravenous; Male; Medical sciences; Middle Aged; Niacinamide - administration & dosage; Niacinamide - analogs & derivatives; Niacinamide - pharmacokinetics; Niacinamide - pharmacology; Nicorandil; Pharmacology. Drug treatments; Posture; Single-Blind Method; Vasodilator Agents - administration & dosage; Vasodilator Agents - pharmacokinetics; Vasodilator Agents - pharmacology
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/BF00315276

We have studied the effects of intravenous nicorandil, a mixed arterial and venous vasodilator, in 48 healthy volunteers. Nicorandil (20, 28, 39, 54, 74, 103, 144, or 200 micrograms.kg-1) or placebo were given over 5 min to subjects supine (16 subjects, 2 doses) or sitting (32 subjects, 1 dose) in a single-blind crossover design. Electrocardiographic intervals, blood pressure, and heart rate were measured before and for 8 h after dosing. Blood and urine safety laboratory studies were also performed before and after dosing. All intravenous infusions of nicorandil and placebo were well tolerated and there were no clinically important safety concerns. The most frequent adverse event after nicorandil was headache (24 events by 19 subjects), although its occurrence was not strictly dose related. One subject experienced transient symptomatic hypotension (144 micrograms.kg-1). Mean plasma nicorandil concentrations were dose-related and fell with a half-life of 0.7 to 1.2 h. Systemic clearance and volume of distribution tended to decrease as dose increased. Sitting subjects showed marginally lower (< 20%) systemic clearances and larger values of Cmax and AUC. Nicorandil produced dose-related reductions in blood pressure, with consistent statistically significant differences from placebo after the 144 and 200 micrograms.kg-1 doses. The falls in blood pressure were greater for diastolic pressure and in this supine position. At 200 micrograms.kg-1, the mean falls in systolic/diastolic pressures (mm Hg) during the first hour were 10.9/14.7 supine and 6.1/9.1 sitting; systolic pressure returned to baseline after 8 h and diastolic pressure after 4 h.