Visceral pain originating from the upper urinary tract

Pain originating from the upper urinary tract is a common problem and stone colic is one of the most intense pain conditions that can be experienced in the clinic. The pain is difficult to alleviate and often leads to medical attention. In humans, pain mechanisms of the upper urinary tract pain are...

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Bibliographic Details
Published in:Urological research 2010-10, Vol.38 (5), p.345-355
Main Authors: Pedersen, Katja Venborg, Drewes, Asbjørn Mohr, Frimodt-Møller, Poul Christian, Osther, Palle Jørn Sloth
Format: Article
Language:English
Subjects:
Humans
Kidney Diseases - complications
Kidney Diseases - physiopathology
Medical Biochemistry
Medicine
Medicine & Public Health
Nephrology
pain
Pain - etiology
Pain - physiopathology
Pain Management
Renal colic
Renal stone
Review
Ureteral Diseases - complications
Ureteral Diseases - physiopathology
urinary tract
Urology
Viscera
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Summary:Pain originating from the upper urinary tract is a common problem and stone colic is one of the most intense pain conditions that can be experienced in the clinic. The pain is difficult to alleviate and often leads to medical attention. In humans, pain mechanisms of the upper urinary tract pain are still poorly understood, which often leads to a trial and error approach in clinical pain management. Pain from the upper urinary tract seems to have all the characteristics of pure visceral pain, including referred pain with or without hyperalgesia/trophic changes in somatic tissues and viscero-visceral hyperalgesia. However, further studies are needed to better understand these visceral pain mechanisms with regard to optimising pain management. This review gives an introduction to visceral pain in general and upper urinary tract pain in particular, with special reference to pain pathways and pharmacological and non-pharmacological pain modulation.
ISSN:0300-5623
1434-0879
DOI:10.1007/s00240-010-0278-1