High-Resolution Crystal Structure of a Lasso Peptide

Have I got noose for you! Lasso peptides are a growing class of bioactive peptides of microbial origin. The first crystal structure of a member of this family, the glucagon receptor antagonist BI‐32169, shows that the fold is built predominantly by regular secondary structural elements and a tight n...

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Bibliographic Details
Published in:ChemMedChem 2010-10, Vol.5 (10), p.1689-1692
Main Authors: Nar, Herbert, Schmid, Angela, Puder, Carsten, Potterat, Olivier
Format: Article
Language:English
Subjects:
Amino Acid Sequence
BI-32169
bioactive peptides
crystal structures
Crystallography, X-Ray
glucagon receptor antagonists
Humans
lariat protoknots
Molecular Sequence Data
Peptides, Cyclic - chemistry
Protein Structure, Tertiary
Receptors, Glucagon - antagonists & inhibitors
Receptors, Glucagon - metabolism
Streptomyces - metabolism
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Summary:Have I got noose for you! Lasso peptides are a growing class of bioactive peptides of microbial origin. The first crystal structure of a member of this family, the glucagon receptor antagonist BI‐32169, shows that the fold is built predominantly by regular secondary structural elements and a tight network of hydrogen bonds that are partially shielded from solvent by hydrophobic amino acid side chains. This results in an extraordinarily stable structure that is resistant to thermal unfolding or proteolytic digestion, which facilitates its biological function.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201000264