Photosensitization and the nervous system in the planarian Dugesia gonocephala. A histochemical, ultrastructural and behavioral investigation

Photosensitization phenomena may be induced in planarias by eosin and hematoporphyrin, and as a result, dopamine agonistic behavior ("screw-like hyperkinesia") is set up in the animal. Histochemical, ultrastructural and pharmacological investigations have shown that this hyperkinesia is of...

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Bibliographic Details
Published in:Cell and tissue research 1981-01, Vol.215 (2), p.271-279
Main Authors: Palladini, G, Margotta, V, Medolago-Albani, L, Hernandez, M C, Carolei, A, de Michele, T
Format: Article
Language:English
Subjects:
Animals
Eosine Yellowish-(YS) - pharmacology
Haloperidol - pharmacology
Hematoporphyrins - pharmacology
Light - adverse effects
Microscopy, Electron
Movement
Nerve Tissue - drug effects
Nerve Tissue - radiation effects
Planarians - anatomy & histology
Planarians - radiation effects
Reserpine - pharmacology
Turbellaria - radiation effects
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Summary:Photosensitization phenomena may be induced in planarias by eosin and hematoporphyrin, and as a result, dopamine agonistic behavior ("screw-like hyperkinesia") is set up in the animal. Histochemical, ultrastructural and pharmacological investigations have shown that this hyperkinesia is of post-synaptic origin in eosin photosensitization, and of pre-synaptic origin in hematoporphyrin photosensitization. The authors suggest an hypothesis to explain the different activity of the two photosensitizers, and discuss the validity of the experiment with regard to human porphyria.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00239114