Lithium in children of lithium-responding parents

Six offspring of manic-depressive patients, whose parents were lithium responders, were selected on the basis of their incapacitating psychopathology for treatment with lithium. The children ranged in age from 6 to 12. A double-blind, crossover design was used over 16–18 weeks. Weekly ratings were d...

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Bibliographic Details
Published in:Psychiatry research 1981-01, Vol.4 (2), p.171-180
Main Authors: McKnew, Donald H., Cytryn, Leon, Buchsbaum, Monte S., Hamovit, Joel, Lamour, Martine, Rapoport, Judith L., Gershon, Elliot S.
Format: Article
Language:English
Subjects:
Bipolar Disorder - drug therapy
Bipolar Disorder - genetics
Child
children
depression
Electroencephalography
evoked potentials
Evoked Potentials - drug effects
Humans
Lithium
Lithium - blood
Lithium - therapeutic use
Male
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Summary:Six offspring of manic-depressive patients, whose parents were lithium responders, were selected on the basis of their incapacitating psychopathology for treatment with lithium. The children ranged in age from 6 to 12. A double-blind, crossover design was used over 16–18 weeks. Weekly ratings were done, and average evoked potentials (EPs) were measured at each crossover. Two children diagnosed as having a bipolar affective disorder had a clear-cut response to lithium and were strong augmenters on the EP. This, taken together with the similarity of the EP changes on lithium to those occurring in adult patients treated with lithium, supports a physiological parallel between bipolar affective illness in adults and children.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(81)90020-2