"Infectious" Transplantation Tolerance

The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4$^+$ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1993-02, Vol.259 (5097), p.974-977
Main Authors: Qin, Shixin, Cobbold, Stephen P., Pope, Heather, Elliott, James, Kioussis, Dimitris, Davies, Joanna, Waldmann, Herman
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - therapeutic use
Antigens, Differentiation, T-Lymphocyte - analysis
Antigens, Differentiation, T-Lymphocyte - immunology
Biological and medical sciences
CD2 Antigens
CD4 Antigens - immunology
CD4-Positive T-Lymphocytes - immunology
CD8 Antigens - immunology
Donors
Exercise tolerance
Experimental and animal immunopathology. Animal models
Graft rejection
Graft Rejection - immunology
Immune Tolerance
Immunity (Disease)
Immunopathology
Logical Thinking
Lymphocytes
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Mice, Transgenic
Monoclonal antibodies
Rats
Receptors, Immunologic - analysis
Receptors, Immunologic - immunology
Rodents
Skin grafts
Skin Transplantation - immunology
Spleen - immunology
Spleen cells
T lymphocytes
Transplantation immunology
Transplantation tolerance
Transplants & implants
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Description
Summary:The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4$^+$ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naïve lymphocytes. This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8094901