Precocious puberty due to a lipid-cell tumour of the ovary

A 4-year-old girl with a lipid cell tumour of the ovary showed isosexual precocious pseudopuberty. The endocrine activity of the tumour led to elevated plasma levels of dehydroepiandrosterone sulphate, oestradiol, testosterone and androstenedione. After tumour resection the clinical signs of abnorma...

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Bibliographic Details
Published in:European journal of pediatrics 1993, Vol.152 (1), p.12-14
Main Authors: DENGG, K, FINK, F. M, HEITGER, A, TABARELLI, M, KRECZY, A, GLATZL, J, BERGER, H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Buserelin - therapeutic use
Child, Preschool
Female
Female genital diseases
Follicle Stimulating Hormone - blood
Gynecology. Andrology. Obstetrics
Humans
Luteinizing Hormone - blood
Medical sciences
Ovarian Neoplasms - blood
Ovarian Neoplasms - complications
Puberty, Precocious - blood
Puberty, Precocious - drug therapy
Puberty, Precocious - etiology
Recurrence
Tumors
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Summary:A 4-year-old girl with a lipid cell tumour of the ovary showed isosexual precocious pseudopuberty. The endocrine activity of the tumour led to elevated plasma levels of dehydroepiandrosterone sulphate, oestradiol, testosterone and androstenedione. After tumour resection the clinical signs of abnormal hormonal stimulation disappeared within 10 months. The girl developed precocious puberty again 2 years later without any sign of relapse. Therapy with luteinizing hormone releasing hormone agonist was effective although premature activation of the hypothalamic-pituitary-gonadal axis could not clearly be demonstrated by hormonal investigations.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF02072508