Hemodynamic tolerability and anti-ischemic efficacy of high dose intravenous diltiazem in patients with normal versus impaired ventricular function

Objectives. This study was designed to compare the acute systemic and coronary hemodynamic effects of high doses of intravenous diltiazem in patients with normal versus impaired left ventricular function, investigate the safety of this drug and compare its anti-ischemic potential in these two patien...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 1993-03, Vol.21 (3), p.709-720
Main Authors: Remme, Willem J., Krauss, X.Hanno, van Hoogenhuyze, Diederik C.A., Kruyssen, Dick A.C.M.
Format: Article
Language:English
Subjects:
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Cardiac Catheterization
Cardiac Pacing, Artificial
Cardiovascular system
Coronary Circulation - drug effects
Coronary Disease - drug therapy
Coronary Disease - physiopathology
Diltiazem - administration & dosage
Diltiazem - therapeutic use
Female
Hemodynamics - drug effects
Humans
Injections, Intravenous
Male
Medical sciences
Middle Aged
Myocardial Contraction - drug effects
Pharmacology. Drug treatments
Ventricular Function, Left - drug effects
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Summary:Objectives. This study was designed to compare the acute systemic and coronary hemodynamic effects of high doses of intravenous diltiazem in patients with normal versus impaired left ventricular function, investigate the safety of this drug and compare its anti-ischemic potential in these two patient groups during pacing-induced stress. Background. Because coronary hemodynamic effects and negative inotropic properties of diltiazem are dose related, high dose intravenous diltiazem may improve anti-ischemic efficacy but may not be tolerated in patients with impaired cardiac function. Methods. High dose intravenous diltiazem, 0.4 mg/kg for 5 min followed by 0.4 mg/kg for 10 min, was administered to 23 normotensive patient's with coronary artery disease, 11 (group A) with normal and 12 (group B) with impaired ventricular function (ejection fraction
ISSN:0735-1097
1558-3597
DOI:10.1016/0735-1097(93)90104-9