Auditory event-related potentials in schizophrenia and depression

Event-related potentials in two auditory target detection paradigms and two auditory paradigms without overt tasks were studied in 22 schizophrenic, 21 depressed, and 28 matched control subjects meeting Research Diagnostic Criteria. In the target detection paradigms, schizophrenics showed a pattern...

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Bibliographic Details
Published in:Psychiatry research 1981-04, Vol.4 (2), p.199-212
Main Authors: Roth, Walton T., Pfefferbaum, Adolf, Kelly, Andrew F., Berger, Philip A., Kopell, Bert S.
Format: Article
Language:English
Subjects:
Adult
Attention
depression
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Discrimination Learning
Electroencephalography
event-related potentials
Evoked Potentials, Auditory
Humans
Loudness Perception
Male
Reaction Time
Schizophrenia
Schizophrenia - diagnosis
Schizophrenic Psychology
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Summary:Event-related potentials in two auditory target detection paradigms and two auditory paradigms without overt tasks were studied in 22 schizophrenic, 21 depressed, and 28 matched control subjects meeting Research Diagnostic Criteria. In the target detection paradigms, schizophrenics showed a pattern of reduced N120 amplitude and shorter P200 latency to frequently occuring tones, and reduced P300 and Slow Wave amplitude to infrequent target and nontarget tones. This pattern is consistent with impaired selective attention for stimuli. For depressed patients these variables were generally intermediate between those of schizophrenics and controls. In the other paradigms N120 latency was greater for schizophrenics, and P200 amplitude was less for depressed patients.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(81)90023-8