Hormonal Requirements for Growth of Arterial Smooth Muscle Cells in vitro: An Endocrine Approach to Atherosclerosis

In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Seru...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-05, Vol.212 (4496), p.818-820
Main Authors: Weinstein, Robert, Stemerman, Michael B., Maciag, Thomas
Format: Article
Language:English
Subjects:
Animals
Aorta, Abdominal - cytology
Arteriosclerosis
Cell Division - drug effects
Cell growth
Cells, Cultured
Culture Media
Cultured cells
Endocrinology, Experimental
Fetus
Growth Substances - pharmacology
Hormones
Hormones - pharmacology
Insulin - pharmacology
Lymphocytes
Microelectromechanical systems
Muscle, Smooth, Vascular - cytology
Nodules
Rats
Smooth muscle myocytes
Somatic cells
Testes
Transferrin - pharmacology
Vascular smooth muscle
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Summary:In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Serum-free, hormone-supplemented cultures spontaneously formed atherosclerotic plaque-like nodules. Thus atherosclerosis may be mediated by a complex endocrine system.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7013068