A New Bastadin from the Sponge Psammaplysilla purpurea

A new bastadin 2 and the previously reported bastadins 5 [3], 7 [4], and 12 (formerly bastadin 9) [5] were isolated from the Verongid sponge Psammaplysilla purpurea collected in Pohnpei. Compound 2 is mildly cytotoxic against several cell lines and inhibits the enzymes topoisomerase II and dehydrofo...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1993-01, Vol.56 (1), p.153-157
Main Authors: Carney, John R, Scheuer, Paul J, Kelly-Borges, Michelle
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Carbohydrate Sequence
Cell Survival - drug effects
Folic Acid Antagonists
General pharmacology
Halogenated Diphenyl Ethers
Haplorhini
Humans
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Molecular Sequence Data
Peptides, Cyclic
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenyl Ethers - chemistry
Phenyl Ethers - isolation & purification
Phenyl Ethers - pharmacology
Porifera - chemistry
Topoisomerase II Inhibitors
Tumor Cells, Cultured - drug effects
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Summary:A new bastadin 2 and the previously reported bastadins 5 [3], 7 [4], and 12 (formerly bastadin 9) [5] were isolated from the Verongid sponge Psammaplysilla purpurea collected in Pohnpei. Compound 2 is mildly cytotoxic against several cell lines and inhibits the enzymes topoisomerase II and dehydrofolate reductase.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50091a025