Is Increased Amplitude of Contingent Negative Variation in Migraine Due to Cortical Hyperactivity or to Reduced Habituation?

The aim of this study was to compare the habituation kinetics of contingent negative variation (CNV) between 12 migraineurs without aura and matched healthy controls. CNV was studied with a 3 sec interval between the warning stimulus (WS) and the imperative stimulus (IS). The data from (a) the total...

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Bibliographic Details
Published in:Cephalalgia 1993-02, Vol.13 (1), p.37-41
Main Authors: Kropp, Peter, Gerber, Wolf-Dieter
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adult
Analysis of Variance
Biological and medical sciences
Brain - physiopathology
Contingent negative variation
Contingent Negative Variation - physiology
Female
habituation
Habituation, Psychophysiologic - physiology
Humans
Male
Medical sciences
Middle Aged
migraine
Migraine Disorders - physiopathology
Neurology
Regression Analysis
Time Factors
Vascular diseases and vascular malformations of the nervous system
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Summary:The aim of this study was to compare the habituation kinetics of contingent negative variation (CNV) between 12 migraineurs without aura and matched healthy controls. CNV was studied with a 3 sec interval between the warning stimulus (WS) and the imperative stimulus (IS). The data from (a) the total interval (WS-IS), (b) early component, and (c) late component were analyzed. During successive trials the habituation kinetics were determined using regression analysis. On CNV averaged over 32 trials, migraine patients had a significantly higher negativity in the total interval compared to controls. When sequential blocks of four trials were analyzed, the most significant finding in migraineurs was lack of habituation of the early CNV component. The present study indicates that a delayed habituation, rather than a general increased cortical activity, is responsible for the CNV abnormalities in migraine without aura. We suggest that migraineurs between attacks not only have a cortical hyperexcitability, but also a lack of cortical inhibition causing delayed habituation.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1993.1301037.x