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A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors
Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNFα as a template for the generation of the CD40L model. The soundness of th...
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Published in: | International immunology 1993-02, Vol.5 (2), p.233-238 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNFα as a template for the generation of the CD40L model. The soundness of the model-building algorithms was verified by constructing a 3-D model of TNFβ and comparing it to its crystallographically determined structure. The CD40L sequence is entirety compatible with the ‘Jelly-roll’ β-strand structure characteristic of the TNFs. Like the TNFs, CD40L is predicted to form a compact trimer, although the interactions between monomers are distinct from those found in the TNFs. The model predicts which regions of CD40L could interact with its receptor(s) and which amino acids are essential for the maintenance of its trimeric structure. |
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ISSN: | 0953-8178 1460-2377 |
DOI: | 10.1093/intimm/5.2.233 |