Sex and surgical stress

The endocrine and metabolic response to anaesthesia and surgery was studied in 12 men and eight women undergoing elective total hip replacement using buprenorphine as the intra‐ and postoperative analgesic. Plasma glucose, cortisol and prolactin were measured, and the results obtained for men and wo...

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Bibliographic Details
Published in:Anaesthesia 1981-03, Vol.36 (3), p.263-267
Main Authors: MOORE, R.A., SMITH, R.F., McQUAY, H.J., BULLINGHAM, R.E.S.
Format: Article
Language:English
Subjects:
Aged
Blood Glucose - metabolism
Buprenorphine - therapeutic use
cortisol
Female
Hormone
Humans
Hydrocortisone - blood
Intraoperative Period
Male
Metabolism
Middle Aged
Postoperative Complications - blood
Postoperative Complications - prevention & control
Postoperative Period
prolactin
Prolactin - blood
Sex Factors
Stress, Physiological - blood
Stress, Physiological - prevention & control
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Summary:The endocrine and metabolic response to anaesthesia and surgery was studied in 12 men and eight women undergoing elective total hip replacement using buprenorphine as the intra‐ and postoperative analgesic. Plasma glucose, cortisol and prolactin were measured, and the results obtained for men and women compared. Statistically significant differences between men and women were found for prolactin during and after operation, and also for cortisol postoperatively. Men, but not women, demonstrated a significant fall in plasma cortisol following a dose of buprenorphine after operation. These results are discussed in relation to known procedures for ablating the stress response and to the neuroendocrine effects of opiate agonists and partial agonists.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1981.tb10198.x