Human γ-interferon expression in the mammary gland of transgenic mice

Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as...

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Bibliographic Details
Published in:FEBS letters 1993-03, Vol.319 (1), p.181-184
Main Authors: Dobrovolsky, V.N., Lagutin, O.V., Vinogradova, T.V., Frolova, I.S., Kuznetsov, V.P., Larionov, O.A.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
DNA - genetics
Female
Gene Expression
Human
Humans
Interferon-gamma - analysis
Interferon-gamma - genetics
Lactation
Lactoglobulins - genetics
Mammary Glands, Animal - chemistry
Mammary Glands, Animal - metabolism
Mice
Mice, Transgenic
Milk
Milk - chemistry
Molecular Sequence Data
Ovine
Recombinant Fusion Proteins - genetics
RNA, Messenger - analysis
Transgenic mouse
β-Lactoglobulin
γ-Interferon
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Summary:Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IU ml . The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)80063-Z