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Human γ-interferon expression in the mammary gland of transgenic mice
Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as...
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| Published in: | FEBS letters 1993-03, Vol.319 (1), p.181-184 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c420Z-668850c4e4deb4038929cb846c2d6589a3f5b1c7a80c371d616cf17fe7b3b3e23 |
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| cites | cdi_FETCH-LOGICAL-c420Z-668850c4e4deb4038929cb846c2d6589a3f5b1c7a80c371d616cf17fe7b3b3e23 |
| container_end_page | 184 |
| container_issue | 1 |
| container_start_page | 181 |
| container_title | FEBS letters |
| container_volume | 319 |
| creator | Dobrovolsky, V.N. Lagutin, O.V. Vinogradova, T.V. Frolova, I.S. Kuznetsov, V.P. Larionov, O.A. |
| description | Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800
IU
ml
. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male. |
| doi_str_mv | 10.1016/0014-5793(93)80063-Z |
| format | article |
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IU
ml
. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(93)80063-Z</identifier><identifier>PMID: 8454053</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Base Sequence ; DNA - genetics ; Female ; Gene Expression ; Human ; Humans ; Interferon-gamma - analysis ; Interferon-gamma - genetics ; Lactation ; Lactoglobulins - genetics ; Mammary Glands, Animal - chemistry ; Mammary Glands, Animal - metabolism ; Mice ; Mice, Transgenic ; Milk ; Milk - chemistry ; Molecular Sequence Data ; Ovine ; Recombinant Fusion Proteins - genetics ; RNA, Messenger - analysis ; Transgenic mouse ; β-Lactoglobulin ; γ-Interferon</subject><ispartof>FEBS letters, 1993-03, Vol.319 (1), p.181-184</ispartof><rights>1993</rights><rights>FEBS Letters 319 (1993) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420Z-668850c4e4deb4038929cb846c2d6589a3f5b1c7a80c371d616cf17fe7b3b3e23</citedby><cites>FETCH-LOGICAL-c420Z-668850c4e4deb4038929cb846c2d6589a3f5b1c7a80c371d616cf17fe7b3b3e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001457939380063Z$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8454053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobrovolsky, V.N.</creatorcontrib><creatorcontrib>Lagutin, O.V.</creatorcontrib><creatorcontrib>Vinogradova, T.V.</creatorcontrib><creatorcontrib>Frolova, I.S.</creatorcontrib><creatorcontrib>Kuznetsov, V.P.</creatorcontrib><creatorcontrib>Larionov, O.A.</creatorcontrib><title>Human γ-interferon expression in the mammary gland of transgenic mice</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800
IU
ml
. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Human</subject><subject>Humans</subject><subject>Interferon-gamma - analysis</subject><subject>Interferon-gamma - genetics</subject><subject>Lactation</subject><subject>Lactoglobulins - genetics</subject><subject>Mammary Glands, Animal - chemistry</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Molecular Sequence Data</subject><subject>Ovine</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Transgenic mouse</subject><subject>β-Lactoglobulin</subject><subject>γ-Interferon</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqNkN9KwzAUxoMoc07fQKFXohfVpEnT9EbQsTpB8EZvdhPS9HRG-mcmrbrn8j18Jtt17FKEQJLzfefLyQ-hU4KvCCb8GmPC_DCK6UVMLwXGnPqLPTQmIqI-ZVzso_HOcoiOnHvD3V2QeIRGgoUMh3SMknlbqsr7-fZN1YDNwdaVB18rC86Z7mgqr3kFr1RlqezaWxaqyrw69xqrKreEymivNBqO0UGuCgcn232CXpLZ83TuPz7dP0xvH33NArzwORcixJoByyBlmIo4iHUqGNdBxkMRK5qHKdGREljTiGSccJ2TKIcopSmFgE7Q-ZC7svV7C66RpXEaim4sqFsno5AHEY1FZ2SDUdvaOQu5XFnTf0ESLHt8smcjezayWxt8ctG1nW3z27SEbNe05dXpyaB_mgLW_8qUyewu6IW-HtNNtX_oZgiCjtaHASudNlBpyIwF3cisNn9P-gvg_pLZ</recordid><startdate>19930315</startdate><enddate>19930315</enddate><creator>Dobrovolsky, V.N.</creator><creator>Lagutin, O.V.</creator><creator>Vinogradova, T.V.</creator><creator>Frolova, I.S.</creator><creator>Kuznetsov, V.P.</creator><creator>Larionov, O.A.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930315</creationdate><title>Human γ-interferon expression in the mammary gland of transgenic mice</title><author>Dobrovolsky, V.N. ; 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The concentration of active hIFN-g in the milk was estimated as being ca. 1800
IU
ml
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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1993-03, Vol.319 (1), p.181-184 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75627398 |
| source | ScienceDirect® |
| subjects | Animals Base Sequence DNA - genetics Female Gene Expression Human Humans Interferon-gamma - analysis Interferon-gamma - genetics Lactation Lactoglobulins - genetics Mammary Glands, Animal - chemistry Mammary Glands, Animal - metabolism Mice Mice, Transgenic Milk Milk - chemistry Molecular Sequence Data Ovine Recombinant Fusion Proteins - genetics RNA, Messenger - analysis Transgenic mouse β-Lactoglobulin γ-Interferon |
| title | Human γ-interferon expression in the mammary gland of transgenic mice |
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