Synergistic Interaction of D1 and D2 Dopamine Receptors in the Modulation of the Reinforcing Effect of Brain Stimulation

Rats were trained to press a bar for hypothalamic stimulation, and a frequency-response function was plotted. Quinpirole (a selective D2 agonist) facilitated self-stimulation when injected alone but failed to show the facilitatory effect when injected either 1 hr before or 1 hr after injection of SC...

Full description

Saved in:
Bibliographic Details
Published in:Behavioral neuroscience 1993-02, Vol.107 (1), p.161-165
Main Authors: Nakajima, Shinshu, Liu, Xinhe, Lau, Chin Loong
Format: Article
Language:English
Subjects:
alpha-Methyltyrosine
Animal
Animal training
Animals
Behavioral psychophysiology
Benzazepines - pharmacology
Biological and medical sciences
Brain
Brain Stimulation
Dopamine Agents - pharmacology
Dopamine Agonists
Dopamine Antagonists
Dose-Response Relationship, Drug
Electric Stimulation
Ergolines - pharmacology
Fundamental and applied biological sciences. Psychology
Hypothalamus
Hypothalamus - drug effects
Hypothalamus - physiology
Methyltyrosines - pharmacology
Neural Receptors
Neurotransmission and behavior
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Quinpirole
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 - drug effects
Receptors, Dopamine D1 - physiology
Receptors, Dopamine D2 - drug effects
Receptors, Dopamine D2 - physiology
Rodents
Self Stimulation - drug effects
Self Stimulation - physiology
Self-Reinforcement
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Tyrosine 3-Monooxygenase - antagonists & inhibitors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rats were trained to press a bar for hypothalamic stimulation, and a frequency-response function was plotted. Quinpirole (a selective D2 agonist) facilitated self-stimulation when injected alone but failed to show the facilitatory effect when injected either 1 hr before or 1 hr after injection of SCH 23390 (a D1 antagonist). Injection of reserpine followed by α-methyl- p -tyrosine virtually eliminated self-stimulation. Subsequent injection of either SKF 38393 (a D1 agonist) alone or quinpirole alone did not restore self-stimulation, but a combination of quinpirole and SKF 38393 did. The results suggest that a D2 dopamine agonist facilitates the reinforcing effect of brain stimulation only if D1 receptors are activated by endogenous dopamine or by an exogenous agonist.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.107.1.161