Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases

Histologic features of an invasive mediastinal tumor found in a 25‐year‐old woman fulfilled the accepted criteria for diagnosis of predominantly lymphocytic thymoma. Histochemical and cell marker studies indicated that the neoplasm contained a preponderance of T lymphocytes. After surgical debulking...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1981-04, Vol.47 (8), p.2036-2043
Main Authors: Wick, Mark R., Nichols, William C., Ingle, James N., Bruckman, James E., Okazaki, Haruo
Format: Article
Language:English
Subjects:
Adult
Brain Neoplasms - secondary
Brain Stem
Cranial Nerve Neoplasms - secondary
Female
Humans
Mediastinal Neoplasms - pathology
Mesencephalon - pathology
Nervous System Neoplasms - secondary
Oculomotor Nerve - pathology
Oculomotor Nerve - ultrastructure
Peripheral Nervous System Neoplasms - secondary
T-Lymphocytes - pathology
Thymoma - pathology
Thymoma - radiotherapy
Thymoma - surgery
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Histologic features of an invasive mediastinal tumor found in a 25‐year‐old woman fulfilled the accepted criteria for diagnosis of predominantly lymphocytic thymoma. Histochemical and cell marker studies indicated that the neoplasm contained a preponderance of T lymphocytes. After surgical debulking of the mass, aggressive radiotherapy and chemotherapy eradicated all evidence of thoracic disease. However, six months after the initial diagnosis, rapid development of cranial nerve and brainstem metastases—without detectable recurrent disease elsewhere—resulted in the patient's death. Autopsy examination revealed the presence of peripheral nerve metastases as well. A review of the literature disclosed fewer than 10 cases of central nervous system metastasis from thymoma. In only two of these were there clinicopathologic features similar to those seen in this case.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19810415)47:8<2036::AID-CNCR2820470823>3.0.CO;2-9