Effects of hycanthone and praziquantel on monoamine oxidase and cholinesterases in Schistosoma mansoni

The effects of hycanthone and praziquantel on the activities of monoamine oxidases and cholinesterases were studied in the 600-g supernatant from homogenates of Schistosoma mansoni and mouse liver or brain. Hycanthone was shown to be a very potent inhibitor of monoamine oxidases from worms and mouse...

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Bibliographic Details
Published in:The Journal of parasitology 1981-02, Vol.67 (1), p.20-23
Main Authors: Kim, R.A, Lukacs, J, Tanaka, R.D, Macinnis, A.J
Format: Article
Language:English
Subjects:
Amines
Animals
Biochemistry
Brain - enzymology
Cholinergic receptors
Cholinesterases - metabolism
Dose-Response Relationship, Drug
Enzymes
Hycanthone - pharmacology
Isoquinolines - pharmacology
Liver
Liver - enzymology
Mice
Monoamine Oxidase - metabolism
Oxidases
Pain
Parasites
Parasitism
Phosphates
Praziquantel - pharmacology
Receptors
Schistosoma mansoni - drug effects
Schistosoma mansoni - enzymology
Thioxanthenes - pharmacology
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Summary:The effects of hycanthone and praziquantel on the activities of monoamine oxidases and cholinesterases were studied in the 600-g supernatant from homogenates of Schistosoma mansoni and mouse liver or brain. Hycanthone was shown to be a very potent inhibitor of monoamine oxidases from worms and mouse liver. Hycanthone also inhibited the specific and nonspecific cholinesterases of S. mansoni, but cholinesterase from mouse brain was not affected significantly by this drug. Praziquantel showed no effect on monoamine oxidase from mouse liver or the parasite; however, it was slightly inhibitory to S. mansoni cholinesterases at very high concentrations. Mouse brain cholinesterase required an even higher concentration of praziquantel to observe inhibition. The inhibition of monoamine oxidase in S. mansoni by hycanthone adds a new mode of action to our knowledge of this compound, and suggests another possibility for the development of future anthelminthics.
ISSN:0022-3395
1937-2345
DOI:10.2307/3280771