Familial occurrence of meconium ileus

A recurrence rate for meconium ileus of 39% was found among C.F. affected siblings in a study of 488 families with at least one C.F. child born over a 24 year period. The recurrence rate was highly significant and indicated a familial trend for the occurrence of meconium ileus. The findings of the s...

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Bibliographic Details
Published in:European journal of pediatrics 1981-02, Vol.135 (3), p.291-292
Main Authors: Allan, J L, Robbie, M, Phelan, P D, Danks, D M
Format: Article
Language:English
Subjects:
Cystic Fibrosis - genetics
Humans
Infant, Newborn
Infant, Newborn, Diseases - genetics
Intestinal Obstruction - genetics
Meconium
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Summary:A recurrence rate for meconium ileus of 39% was found among C.F. affected siblings in a study of 488 families with at least one C.F. child born over a 24 year period. The recurrence rate was highly significant and indicated a familial trend for the occurrence of meconium ileus. The findings of the study support the existence of genetic heterogeneity in cystic fibrosis.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF00442105