An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives

The relationship between plasma levels of the tricyclic antidepressant desmethylimipramine (DMI) and plasma levels of melatonin-like immunoreactivity was studied in 32 endogenously depressed patients. An inverse correlation between plasma levels of DMI and plasma levels of melatonin-like immunoreact...

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Bibliographic Details
Published in:Psychiatry research 1981-02, Vol.4 (1), p.109-113
Main Authors: Halbreich, Uriel, Weinberg, Uzi, Stewart, Jonathan, Klein, Donald F., Weitzman, Elliot D., Quitkin, Frederic M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Depression - blood
Depression - drug therapy
Depressive Disorder - blood
Depressive Disorder - drug therapy
Desipramine - blood
Desipramine - therapeutic use
Desmethylimipramine
endogenous depression
Female
Humans
Male
Melatonin - blood
melatonin-like immunoreactivity
Middle Aged
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Summary:The relationship between plasma levels of the tricyclic antidepressant desmethylimipramine (DMI) and plasma levels of melatonin-like immunoreactivity was studied in 32 endogenously depressed patients. An inverse correlation between plasma levels of DMI and plasma levels of melatonin-like immunoreactivity was found in the group of clinical responders to the chronic administration of the drug. The nonresponders had higher levels of melatonin-like immunoreactivity at comparable levels of DMI. This findings is consistent with the hypothesis that chronic high plasma levels of DMI may down-regulate the β-adrenergic receptors in man. However, some other homeostatic mechanisms may be involved in the clinical response.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(81)90014-7