A monozygotic twin pregnancy after application of zona rubbing on a frozen-thawed blastocyst

Assisted hatching techniques enhance the success rate of implantation of in-vitro fertilized human embryos. We report here the successful transfer of a frozen-thawed human blastocyst on which we applied a non-invasive zona rubbing technique (reduction of the thickness of the zona pellucida by gentle...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1993, Vol.8 (1), p.127-129
Main Authors: NIJS, M, VANDERZWALMEN, P, SEGAL-BERTIN, G, GEERTS, L, VAN ROOSENDAAL, E, SEGAL, L, SCHOYSMAN-DEBOECK, A, SCHOYSMAN, R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth control
Blastocyst
Cryopreservation
Embryo Transfer - methods
Female
Gynecology. Andrology. Obstetrics
Hot Temperature
Humans
Male
Medical sciences
Micromanipulation - methods
Pregnancy
Pregnancy, Multiple
Sterility. Assisted procreation
Twins, Monozygotic
Zona Pellucida - physiology
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Summary:Assisted hatching techniques enhance the success rate of implantation of in-vitro fertilized human embryos. We report here the successful transfer of a frozen-thawed human blastocyst on which we applied a non-invasive zona rubbing technique (reduction of the thickness of the zona pellucida by gentle rubbing with a microneedle). The implantation in the uterus led to the delivery of healthy monozygotic twins.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137861