123I-metaiodobenzylguanidine scintigraphy in the detection of irregular regional sympathetic innervation in long QT syndrome

• Published in: European heart journal 1993-03, Vol.14 (3), p.316-325
• Main Authors: MÜLLER, K. D., JAKOB, H., NEUZNER, J., GREBE, S. F., SCHLEPPER, M., PITSCHNER, H. F.
• Format: Article
• Language: English
• Subjects: 123I-metaiodobenzyl guanidine; 3-Iodobenzylguanidine; Action Potentials - physiology; Adolescent; Adult; Biological and medical sciences; Cardiovascular system; Case-Control Studies; Child; Electrocardiography; Female; Heart - diagnostic imaging; Heart - innervation; Heart Ventricles - metabolism; Humans; Investigative techniques, diagnostic techniques (general aspects); Iodine Radioisotopes; Iodobenzenes - metabolism; Long QT syndrome; Long QT Syndrome - diagnostic imaging; Long QT Syndrome - metabolism; Long QT Syndrome - physiopathology; Male; Medical sciences; Middle Aged; myocardial scintigraphy; Nerve Endings - metabolism; Nerve Endings - physiopathology; Radionuclide investigations; sympathetic nervous system; Sympathetic Nervous System - diagnostic imaging; Sympathetic Nervous System - metabolism; Sympathetic Nervous System - physiopathology; Sympatholytics - metabolism; Tomography, Emission-Computed, Single-Photon
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/14.3.316

Twelve patients with the long QT syndrome were studied to determine the usefulness of 123I-metaiodobenzylguanidine (MIBG) single-photon emission tomography (SPECT) at 2 h and 6 h after injection; the results were compared to 10 healthy volunteers (controls). Uptake of MIBG in the left ventricle at 2 h after injection was significantly reduced in patients with the long QT syndrome (1.43±0.13) vs 1.66±0.15 in controls, heart-to-mediastinum ratio, P