Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats

When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release aga...

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Bibliographic Details
Published in:Digestive diseases and sciences 1993-04, Vol.38 (4), p.653-659
Main Authors: TADAO BAMBA, ISHIZUKA, Y, HOSODA, S
Format: Article
Language:English
Subjects:
Amylases - drug effects
Amylases - metabolism
Animals
Biliary Tract Surgical Procedures - methods
Biological and medical sciences
Cholecystokinin - antagonists & inhibitors
Cholecystokinin - blood
Cholecystokinin - pharmacology
Exocrine pancreas
Fundamental and applied biological sciences. Psychology
Hypertrophy - chemically induced
Hypertrophy - enzymology
Lipase - drug effects
Lipase - metabolism
Male
Pancreas - drug effects
Pancreas - enzymology
Pancreas - growth & development
Pancreas - metabolism
Pancreas - pathology
Pancreas - surgery
Proglumide - analogs & derivatives
Proglumide - pharmacology
Rats
Rats, Wistar
Secretin - blood
Secretin - drug effects
Time Factors
Trypsinogen - drug effects
Trypsinogen - metabolism
Vertebrates: digestive system
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Summary:When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release against CCK-8 in the pancreatic acini decreased when plasma CCK level was high. These changes in pancreatic growth and pancreatic enzyme secretion caused by PBD were completely inhibited by the CCK-receptor antagonist loxiglumide. From these results, intrinsic CCK was considered to play an important role in both pancreatic enzyme synthesis and proliferation.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf01316796