Interleukin-1-dependent mitogenic responses induced by protoscoleces of Echinococcus multilocularis in murine lymphocytes

Mitogenic effects of protoscoleces (PSCs) of Echinococcus multilocularis on murine lymphocytes were studied. Spleen cells from normal BALB/c mice showed significant proliferative responses when cocultured with PSCs. Proliferative responses were observed in both the T and B cell populations. The PSCs...

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Bibliographic Details
Published in:Journal of leukocyte biology 1993-03, Vol.53 (3), p.233-239
Main Authors: KIZAKI, T, ISHIGE, M, BINGYAN, W, KUMAGAI, M, DAY, N. K, GOOD, R. A, ONOE, K
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
B-Lymphocytes - parasitology
Biological and medical sciences
Cell Adhesion
Echinococcosis - parasitology
Echinococcus - drug effects
Echinococcus - immunology
Echinococcus multilocularis
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immune Sera - pharmacology
Immunobiology
Interleukin-1 - immunology
Interleukin-1 - pharmacology
Lymphocyte Activation - immunology
Lymphocyte Subsets - parasitology
Lymphocytes - parasitology
Lymphokines, interleukins ( function, expression)
Macrophages - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mitogens - immunology
Monocytes - metabolism
Regulatory factors and their cellular receptors
Spleen - cytology
Spleen - metabolism
Spleen - parasitology
T-Lymphocytes - parasitology
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Summary:Mitogenic effects of protoscoleces (PSCs) of Echinococcus multilocularis on murine lymphocytes were studied. Spleen cells from normal BALB/c mice showed significant proliferative responses when cocultured with PSCs. Proliferative responses were observed in both the T and B cell populations. The PSCs also stimulated cells of the macrophage/monocyte lineage to secrete interleukin-1 (IL-1). Depletion of plastic- and Sephadex G-10-adherent cells from the spleen cell population significantly reduced the proliferative responses to PSCs and the low responsiveness was restored by addition of plastic-adherent cells to these cultures. Furthermore, addition of anti-IL-1 serum to the spleen cell cultures stimulated with PSCs completely suppressed the proliferative responses. These findings demonstrate that the mitogenic effect of PSC on lymphocytes depends on IL-1 secreted by cells of macrophage/monocyte lineage.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.53.3.233