Glycosylated derivatives of benzophenone, benzhydrol and benzhydril as potential venous antithrombotic agents

A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or be...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1993-04, Vol.36 (7), p.898-903
Main Authors: Bellamy, Francois, Horton, Derek, Millet, Jean, Picart, Francois, Samreth, Soth, Chazan, Jean Bernard
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Benzhydryl Compounds - chemical synthesis
Benzhydryl Compounds - chemistry
Benzhydryl Compounds - therapeutic use
Benzophenones - chemical synthesis
Benzophenones - chemistry
Benzophenones - therapeutic use
Chemistry
Exact sciences and technology
Fibrinolytic Agents - administration & dosage
Fibrinolytic Agents - chemical synthesis
Fibrinolytic Agents - therapeutic use
Glycosylation
Injections, Intraperitoneal
Injections, Intravenous
Male
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
Rats
Rats, Wistar
Structure-Activity Relationship
Thrombophlebitis - drug therapy
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Summary:A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the beta-D-xylopyranosyl structure in the sugar moiety, were good antithrombotic agents in a rat model of venous thrombosis.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00059a015