Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions

Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT)...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1993, Vol.61(2), pp.141-144
Main Authors: Ogawa, Shin-ichi, Nabeshima, Toshitaka, Kameyama, Tsutomu, Hayashi, Kyozo
Format: Article
Language:English
Subjects:
Amnesia - psychology
Animals
Biological and medical sciences
Cerebral Cortex - drug effects
Cerebral Cortex - enzymology
Choline acetyltransferase (CAT)
Choline O-Acetyltransferase - metabolism
Frontal Lobe - drug effects
Frontal Lobe - enzymology
Injections, Intraventricular
Male
Medical sciences
Nerve growth factor (NGF)
Nerve Growth Factors - pharmacology
Neuropharmacology
Parietal Lobe - drug effects
Parietal Lobe - enzymology
Pharmacology. Drug treatments
Prosencephalon - physiology
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
Stereotaxic Techniques
Water maze
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Summary:Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.61.141