Microencapsulation of Methylglyoxal and Two Derivatives

• Published in: Journal of pharmaceutical sciences 1981-04, Vol.70 (4), p.385-386
• Main Authors: Nozawa, Yasuo, Foxx, Sidney W.
• Format: Article
• Language: English
• Subjects: Aldehydes - administration & dosage; Ascorbic Acid - administration & dosage; Ascorbic Acid - analogs & derivatives; Capsules; decomposition in aqueous solution; Drug Stability; Guanidines - administration & dosage; methylglyoxal bis(guanylhydrazone); Methylglyoxal-preparation of microcapsules of methylglyoxal; Methylglyoxal—preparation of microcapsules of methylglyoxal, methylglyoxal bis(guanylhydrazone), or methylglyoxal-ascorbic acid complex, decomposition in aqueous solution; Microencapsulation-symposium; Microencapsulation—symposium, preparation of microcapsules of methylglyoxal and derivatives for gradual release in aqueous solution; Mitoguazone - administration & dosage; or methylglyoxal-ascorbic acid complex; preparation of microcapsules of methylglyoxal and derivatives for gradual release in aqueous solution; Pyruvaldehyde - administration & dosage; Pyruvaldehyde - analogs & derivatives; Release-of microcapsules of methylglyoxal; Release—of microcapsules of methylglyoxal, methylglyoxal bis(guanylhydrazone), or methylglyoxal-ascorbic acid complex, decomposition in aqueous solution; Solubility; Space life sciences; Time Factors
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600700410

Microcapsules of methylglyoxal, methylglyoxal bis(guanylhydrazone), and methylglyoxal-ascorbic acid condensation complex were prepared and release curves were determined. The effect of various concentrations of hydrochloric acid on the decomposition of the ascorbic acid complex was investigated.