Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults : the atherosclerosis risk in communities study

Plasma levels of homocyst(e)ine are elevated in certain patients with occlusive arterial diseases. We extended these findings to asymptomatic adults. We determined plasma homocyst(e)ine levels in 287 pairs of asymptomatic adults. Cases and controls were defined on the basis of intimal-medial thickne...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1993-04, Vol.87 (4), p.1107-1113
Main Authors: MALINOW, M. R, NIETO, F. J, SZKLO, M, CHAMBLESS, L. E, BOND, G
Format: Article
Language:English
Subjects:
Arteriosclerosis - diagnosis
Arteriosclerosis - epidemiology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - epidemiology
Case-Control Studies
Cross-Sectional Studies
Female
Homocysteine - blood
Humans
Male
Medical sciences
Middle Aged
Odds Ratio
Risk Factors
Ultrasonography
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasma levels of homocyst(e)ine are elevated in certain patients with occlusive arterial diseases. We extended these findings to asymptomatic adults. We determined plasma homocyst(e)ine levels in 287 pairs of asymptomatic adults. Cases and controls were defined on the basis of intimal-medial thickness of the carotid wall as measured by B-mode ultrasound. Study subjects had no history of atherosclerotic disease and were selected from a probability sample of 15,800 men and women between 45 and 64 years old. Subjects with thickened intimal-medial carotid walls (cases) had higher plasma homocyst(e)ine levels than controls (p < 0.001). The odds ratio for having a thickened carotid artery wall was 3.15 (p < 0.001) for subjects in the top quintile of plasma homocyst(e)ine levels (> 10.5 mumol/L) compared with those in the bottom quintile (< 5.88 mumol/L). The present study as well as observations on the common occurrence of elevated plasma homocyst(e)ine levels in patients with occlusive arterial diseases suggest that clinical trials should be conducted to determine whether normalization of hyperhomocyst(e)inemia may prevent progression of atherosclerosis.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.87.4.1107