Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus

Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients al...

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Bibliographic Details
Published in:The Lancet (British edition) 1993-04, Vol.341 (8850), p.923-925
Main Authors: Vaarala, O., Aho, K., Palosuo, T., Alfthan, G., Jauhiainen, M., Leirisalo-Repo, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies - blood
Antibodies, Anticardiolipin - blood
Arteriosclerosis - epidemiology
Arteriosclerosis - etiology
Arteriosclerosis - immunology
Biological and medical sciences
Cross Reactions
Disease
Enzyme-Linked Immunosorbent Assay
Female
Finland - epidemiology
Hospitals, University
Humans
Immunity (Disease)
Immunoglobulin G - immunology
Lipoproteins, LDL - immunology
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - immunology
Male
Medical research
Medical sciences
Middle Aged
Predictive Value of Tests
Proteins
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Thromboembolism
Thrombosis - etiology
Thrombosis - immunology
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Summary:Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients also had raised concentrations of IgG anticardiolipin antibodies. Binding of anticardiolipin antibodies to solid-phase cardiolipin was inhibited by oxidised LDL but not by native LDL in 16 of 21 sera from SLE patients. These observations suggest crossreactivity between antiphospholipid antibodies, which are closely associated with thrombosis in SLE, and antibodies to oxidised LDL, thus providing a possible link between thrombotic and atherosclerotic complications in SLE.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(93)91213-6