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Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus
Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients al...
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| Published in: | The Lancet (British edition) 1993-04, Vol.341 (8850), p.923-925 |
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| container_issue | 8850 |
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| container_title | The Lancet (British edition) |
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| creator | Vaarala, O. Aho, K. Palosuo, T. Alfthan, G. Jauhiainen, M. Leirisalo-Repo, M. |
| description | Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients also had raised concentrations of IgG anticardiolipin antibodies. Binding of anticardiolipin antibodies to solid-phase cardiolipin was inhibited by oxidised LDL but not by native LDL in 16 of 21 sera from SLE patients. These observations suggest crossreactivity between antiphospholipid antibodies, which are closely associated with thrombosis in SLE, and antibodies to oxidised LDL, thus providing a possible link between thrombotic and atherosclerotic complications in SLE. |
| doi_str_mv | 10.1016/0140-6736(93)91213-6 |
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Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients also had raised concentrations of IgG anticardiolipin antibodies. Binding of anticardiolipin antibodies to solid-phase cardiolipin was inhibited by oxidised LDL but not by native LDL in 16 of 21 sera from SLE patients. These observations suggest crossreactivity between antiphospholipid antibodies, which are closely associated with thrombosis in SLE, and antibodies to oxidised LDL, thus providing a possible link between thrombotic and atherosclerotic complications in SLE.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(93)91213-6</identifier><identifier>PMID: 8096266</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Aged ; Antibodies - blood ; Antibodies, Anticardiolipin - blood ; Arteriosclerosis - epidemiology ; Arteriosclerosis - etiology ; Arteriosclerosis - immunology ; Biological and medical sciences ; Cross Reactions ; Disease ; Enzyme-Linked Immunosorbent Assay ; Female ; Finland - epidemiology ; Hospitals, University ; Humans ; Immunity (Disease) ; Immunoglobulin G - immunology ; Lipoproteins, LDL - immunology ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - immunology ; Male ; Medical research ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Proteins ; Sarcoidosis. 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Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients also had raised concentrations of IgG anticardiolipin antibodies. Binding of anticardiolipin antibodies to solid-phase cardiolipin was inhibited by oxidised LDL but not by native LDL in 16 of 21 sera from SLE patients. 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaarala, O.</au><au>Aho, K.</au><au>Palosuo, T.</au><au>Alfthan, G.</au><au>Jauhiainen, M.</au><au>Leirisalo-Repo, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1993-04-10</date><risdate>1993</risdate><volume>341</volume><issue>8850</issue><spage>923</spage><epage>925</epage><pages>923-925</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Serum lipoproteins contain phospholipids and modified low-density lipoprotein (LDL) may thus act as a target for antiphospholipid antibodies. Raised concentrations of IgG antibodies against oxidised LDL were found in 47 of 61 (80%) patients with systemic lupus erythematosus (SLE). 46% of patients also had raised concentrations of IgG anticardiolipin antibodies. Binding of anticardiolipin antibodies to solid-phase cardiolipin was inhibited by oxidised LDL but not by native LDL in 16 of 21 sera from SLE patients. These observations suggest crossreactivity between antiphospholipid antibodies, which are closely associated with thrombosis in SLE, and antibodies to oxidised LDL, thus providing a possible link between thrombotic and atherosclerotic complications in SLE.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8096266</pmid><doi>10.1016/0140-6736(93)91213-6</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Aged Antibodies - blood Antibodies, Anticardiolipin - blood Arteriosclerosis - epidemiology Arteriosclerosis - etiology Arteriosclerosis - immunology Biological and medical sciences Cross Reactions Disease Enzyme-Linked Immunosorbent Assay Female Finland - epidemiology Hospitals, University Humans Immunity (Disease) Immunoglobulin G - immunology Lipoproteins, LDL - immunology Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - immunology Male Medical research Medical sciences Middle Aged Predictive Value of Tests Proteins Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Thromboembolism Thrombosis - etiology Thrombosis - immunology |
| title | Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus |
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