Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun

The gold standard treatment of Old World leishmaniasis, a common tropical parasitic infestation, is intralesional meglumine antimoniate injection. Mesotherapy is a new minimally invasive method of administration of variable substances to the skin. Comparison of the efficacy and adverse effects of tr...

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Bibliographic Details
Published in:International journal of dermatology 2010-09, Vol.49 (9), p.1034-1037
Main Authors: MANSOUR NASSIRI KASHANI, SADR, Bardia, MOHAMMAD ALI NILFOROUSHZADEH, ARASTEH, Mahfar, BABAKOOHI, Shahab, FIROOZ, Alireza
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Biological and medical sciences
Child
Dermatology
Female
Human protozoal diseases
Humans
Infectious diseases
Injections, Intralesional - instrumentation
Injections, Intralesional - methods
Leishmaniasis, Cutaneous - drug therapy
Leshmaniasis
Male
Medical sciences
Meglumine - administration & dosage
Mesotherapy - instrumentation
Organometallic Compounds - administration & dosage
Pain - prevention & control
Parasitic diseases
Protozoal diseases
Treatment Outcome
Young Adult
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Summary:The gold standard treatment of Old World leishmaniasis, a common tropical parasitic infestation, is intralesional meglumine antimoniate injection. Mesotherapy is a new minimally invasive method of administration of variable substances to the skin. Comparison of the efficacy and adverse effects of treatment of leishmaniasis with intralesional injection of meglumine antimoniate using conventional method and mesotherapy method. Eighty-five patients with proven leishmaniasis were recruited and randomly treated by one of the two methods, either by conventional injection or by mesotherapy administration weekly. Lesion characteristics were evaluated at every treatment session as well as 1 week, 1 month and 3 months after cessation of treatment. The improvement in lesions was similar in both groups, while it was noted sooner in mesotherapy group with less amount of drug usage (P = 0.005 and 0.016 respectively). Also, patients treated with mesotherapy experienced less pain severity (P = 0.005). Mesotherapy is a safe and effective method of meglumine antimoniate injection for the treatment of cutaneous leishmaniasis and is less painful.
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2010.04523.x