Ovarian tumor marker HE4 is differently expressed during the phases of the menstrual cycle in healthy young women

The objective of the present study was to investigate in healthy young women the fluctuations in serum concentration of human epididymal secretory protein human epididymis-specific protein 4 (HE4) and CA125 during the phases of the menstrual cycle and the correlation between HE4 and CA125 values and...

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Bibliographic Details
Published in:Tumor biology 2010-10, Vol.31 (5), p.411-415
Main Authors: Anastasi, Emanuela, Granato, Teresa, Marchei, Giulia Giovanna, Viggiani, Valentina, Colaprisca, Barbara, Comploj, Sara, Reale, Maria Gabriella, Frati, Luigi, Midulla, Cecilia
Format: Article
Language:English
Subjects:
Age
Age Factors
beta-Defensins
Biomarkers
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Biomedicine
CA-125 Antigen - blood
Cancer Research
Epididymal Secretory Proteins - analysis
Epididymal Secretory Proteins - biosynthesis
Female
Follicular Phase - blood
Gene expression
Humans
Luteal Phase - blood
Membrane Proteins - blood
Menstruation
Ovarian cancer
Ovarian Neoplasms - blood
Proteins
Radioimmunoassay
Research Article
Young adults
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Summary:The objective of the present study was to investigate in healthy young women the fluctuations in serum concentration of human epididymal secretory protein human epididymis-specific protein 4 (HE4) and CA125 during the phases of the menstrual cycle and the correlation between HE4 and CA125 values and age. Forty women with regular menstrual cycles were included in the study. Pelvic and transvaginal ultrasound were performed in order to exclude ovarian pathologies. Blood samples were collected at follicular (FP), ovulatory (OP), and luteal (LP) phases of the hormonal cycle. The values of HE4 (expressed as picomoles per liter) observed were (mean ± SEM) 39.1 ± 1.1 (FP), 45.3 ± 1.19 (OP), and 42.0 ± 1.3 (LP). The difference between FP and OP was statistically significant ( p  = 0.0002). By contrast, serum CA125 levels (expressed as units per milliliter) were 14.35 ± 0.66 (FP), 13.15 ± 0.54 (OP), and 13.70 ± 0.54 (LP), respectively. The levels of HE4 observed in serum samples of women below 35 years were 37.5 ± 1.28 in the FP, 46.6 ± 1.4 in the OP, and 42.8 ± 1.49 in the LP. In this group, a statistically significant difference was observed in the FP compared with the OP ( p  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-010-0049-1