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Short term effects of levothyroxine treatment in thyroid multinodular disease
The levothyroxine suppressive efficacy in benign thyroid nodules treatment is well described in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study is to evaluate the short term effects of levothyroxine treatment i...
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Published in: | ENDOCRINE JOURNAL 2010, Vol.57(9), pp.803-809 |
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description | The levothyroxine suppressive efficacy in benign thyroid nodules treatment is well described in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical and ultrasonography evaluations of thyroid were monitored at the enrolment and after 6, 12 and 24 months of treatment. In the levothyroxine treated group, after 1 year of treatment, thyroid and dominant nodule volume and number of nodules >0.5 mL significantly decreased from a median of 12.0 to 9.8 mL (p |
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The aim of the present study is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical and ultrasonography evaluations of thyroid were monitored at the enrolment and after 6, 12 and 24 months of treatment. In the levothyroxine treated group, after 1 year of treatment, thyroid and dominant nodule volume and number of nodules >0.5 mL significantly decreased from a median of 12.0 to 9.8 mL (p <0.001), from 1.0 to 0.5 mL (p <0.001) and from 0.5 to 0, respectively. Conversely, in the control group significant augmented values of these parameters were observed (p =0.007, p <0.001 and p <0.001, respectively). Furthermore, these observations were also confirmed by results obtained after a 24 months follow-up period. Our data support previous observations on the clinical usefulness of L-T4 treatment in preventing thyroid and nodule volume and nodule numbers growth. These findings confirm the tendency of benign nodular disease toward progression and the efficacy of TSH suppression in preventing its evolution by means of removing the major growth factor for thyroid nodules still responsive to physiological stimuli.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.K10E-144</identifier><identifier>PMID: 20683172</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Adult ; Female ; Goiter, Nodular - diagnostic imaging ; Goiter, Nodular - drug therapy ; Goiter, Nodular - pathology ; Humans ; Levothyroxine therapy ; Middle Aged ; Multinodular goiter ; Pre-menopausal women ; Premenopause ; Thyroid ; Thyroid Gland - diagnostic imaging ; Thyroid Gland - pathology ; Thyrotropin ; Thyroxine - blood ; Thyroxine - therapeutic use ; Triiodothyronine - blood ; Ultrasonography</subject><ispartof>Endocrine Journal, 2010, Vol.57(9), pp.803-809</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-935f4ff78fa59f9b99e4cc793ff1dde3e8db542686b7dc82791623c6b07590d13</citedby><cites>FETCH-LOGICAL-c658t-935f4ff78fa59f9b99e4cc793ff1dde3e8db542686b7dc82791623c6b07590d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20683172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cesareo, Roberto</creatorcontrib><creatorcontrib>Iozzino, Mario</creatorcontrib><creatorcontrib>Isgrò, Maria Antonietta</creatorcontrib><creatorcontrib>Annunziata, Francesca</creatorcontrib><creatorcontrib>Stasio, Enrico Di</creatorcontrib><creatorcontrib>Ospedale “S.M.Goretti”</creatorcontrib><creatorcontrib>Institute of Biochemistry and Clinical Biochemistry</creatorcontrib><creatorcontrib>Catholic University of Sacred Heart</creatorcontrib><creatorcontrib>Thyroid Disease Ambulatory and Thyroid Echointervention</creatorcontrib><creatorcontrib>Institute of Radiology Ospedale“S.M.Goretti”</creatorcontrib><title>Short term effects of levothyroxine treatment in thyroid multinodular disease</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>The levothyroxine suppressive efficacy in benign thyroid nodules treatment is well described in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical and ultrasonography evaluations of thyroid were monitored at the enrolment and after 6, 12 and 24 months of treatment. In the levothyroxine treated group, after 1 year of treatment, thyroid and dominant nodule volume and number of nodules >0.5 mL significantly decreased from a median of 12.0 to 9.8 mL (p <0.001), from 1.0 to 0.5 mL (p <0.001) and from 0.5 to 0, respectively. Conversely, in the control group significant augmented values of these parameters were observed (p =0.007, p <0.001 and p <0.001, respectively). Furthermore, these observations were also confirmed by results obtained after a 24 months follow-up period. Our data support previous observations on the clinical usefulness of L-T4 treatment in preventing thyroid and nodule volume and nodule numbers growth. These findings confirm the tendency of benign nodular disease toward progression and the efficacy of TSH suppression in preventing its evolution by means of removing the major growth factor for thyroid nodules still responsive to physiological stimuli.</description><subject>Adult</subject><subject>Female</subject><subject>Goiter, Nodular - diagnostic imaging</subject><subject>Goiter, Nodular - drug therapy</subject><subject>Goiter, Nodular - pathology</subject><subject>Humans</subject><subject>Levothyroxine therapy</subject><subject>Middle Aged</subject><subject>Multinodular goiter</subject><subject>Pre-menopausal women</subject><subject>Premenopause</subject><subject>Thyroid</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Gland - pathology</subject><subject>Thyrotropin</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - therapeutic use</subject><subject>Triiodothyronine - blood</subject><subject>Ultrasonography</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNo9kM1P3DAQxS3UChbae09Vbj2F2vH3sUJAUal6KJwtxx53s0pisJ2q_Pd12GV9mJHsN--Nfwh9IviScCy_wuyjS7vLHwRft4SxE7QhlKmWcYbfoQ3WRLVKc32GznPeYUwpZ_QUnXVYKEpkt0E_f29jKk2BNDUQAriSmxiaEf7Gsn1J8d8wQ1MS2DLBXJphbl6vB99My1iGOfpltKnxQwab4QN6H-yY4eOhX6DHm-uHq-_t_a_bu6tv960TXJVWUx5YCFIFy3XQvdbAnJOahkC8BwrK95x1Qoleeqc6qYnoqBM9llxjT-gF-rL3fUrxeYFczDRkB-NoZ4hLNpKLejhblXivdCnmnCCYpzRMNr0Ygs3K0BwYmpWhqQzryOeD-dJP4I8Db9Cq4HYvqK-Ds2Ocx0rJ7OKS5vpr457Fq2mdqCEYc4l1bdJghelaNKGCKbFG3eyddrnYP3CMsqkMboTjblwavZa3HY8Ct7Wpquh_NAif_g</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Cesareo, Roberto</creator><creator>Iozzino, Mario</creator><creator>Isgrò, Maria Antonietta</creator><creator>Annunziata, Francesca</creator><creator>Stasio, Enrico Di</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Short term effects of levothyroxine treatment in thyroid multinodular disease</title><author>Cesareo, Roberto ; Iozzino, Mario ; Isgrò, Maria Antonietta ; Annunziata, Francesca ; Stasio, Enrico Di</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c658t-935f4ff78fa59f9b99e4cc793ff1dde3e8db542686b7dc82791623c6b07590d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Female</topic><topic>Goiter, Nodular - diagnostic imaging</topic><topic>Goiter, Nodular - drug therapy</topic><topic>Goiter, Nodular - pathology</topic><topic>Humans</topic><topic>Levothyroxine therapy</topic><topic>Middle Aged</topic><topic>Multinodular goiter</topic><topic>Pre-menopausal women</topic><topic>Premenopause</topic><topic>Thyroid</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Gland - pathology</topic><topic>Thyrotropin</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - therapeutic use</topic><topic>Triiodothyronine - blood</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cesareo, Roberto</creatorcontrib><creatorcontrib>Iozzino, Mario</creatorcontrib><creatorcontrib>Isgrò, Maria Antonietta</creatorcontrib><creatorcontrib>Annunziata, Francesca</creatorcontrib><creatorcontrib>Stasio, Enrico Di</creatorcontrib><creatorcontrib>Ospedale “S.M.Goretti”</creatorcontrib><creatorcontrib>Institute of Biochemistry and Clinical Biochemistry</creatorcontrib><creatorcontrib>Catholic University of Sacred Heart</creatorcontrib><creatorcontrib>Thyroid Disease Ambulatory and Thyroid Echointervention</creatorcontrib><creatorcontrib>Institute of Radiology Ospedale“S.M.Goretti”</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cesareo, Roberto</au><au>Iozzino, Mario</au><au>Isgrò, Maria Antonietta</au><au>Annunziata, Francesca</au><au>Stasio, Enrico Di</au><aucorp>Ospedale “S.M.Goretti”</aucorp><aucorp>Institute of Biochemistry and Clinical Biochemistry</aucorp><aucorp>Catholic University of Sacred Heart</aucorp><aucorp>Thyroid Disease Ambulatory and Thyroid Echointervention</aucorp><aucorp>Institute of Radiology Ospedale“S.M.Goretti”</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short term effects of levothyroxine treatment in thyroid multinodular disease</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>2010</date><risdate>2010</risdate><volume>57</volume><issue>9</issue><spage>803</spage><epage>809</epage><pages>803-809</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>The levothyroxine suppressive efficacy in benign thyroid nodules treatment is well described in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical and ultrasonography evaluations of thyroid were monitored at the enrolment and after 6, 12 and 24 months of treatment. In the levothyroxine treated group, after 1 year of treatment, thyroid and dominant nodule volume and number of nodules >0.5 mL significantly decreased from a median of 12.0 to 9.8 mL (p <0.001), from 1.0 to 0.5 mL (p <0.001) and from 0.5 to 0, respectively. Conversely, in the control group significant augmented values of these parameters were observed (p =0.007, p <0.001 and p <0.001, respectively). Furthermore, these observations were also confirmed by results obtained after a 24 months follow-up period. Our data support previous observations on the clinical usefulness of L-T4 treatment in preventing thyroid and nodule volume and nodule numbers growth. These findings confirm the tendency of benign nodular disease toward progression and the efficacy of TSH suppression in preventing its evolution by means of removing the major growth factor for thyroid nodules still responsive to physiological stimuli.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>20683172</pmid><doi>10.1507/endocrj.K10E-144</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Female Goiter, Nodular - diagnostic imaging Goiter, Nodular - drug therapy Goiter, Nodular - pathology Humans Levothyroxine therapy Middle Aged Multinodular goiter Pre-menopausal women Premenopause Thyroid Thyroid Gland - diagnostic imaging Thyroid Gland - pathology Thyrotropin Thyroxine - blood Thyroxine - therapeutic use Triiodothyronine - blood Ultrasonography |
title | Short term effects of levothyroxine treatment in thyroid multinodular disease |
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