The stimulatory effect of calcium on Na,K-ATPase of nervous tissue

In the absence of EDTA, lower (Ca super(2+)) values have a pronounced stimulatory effect on Na,K-ATPase. On this basis, it is contended that the normal effect of Ca super(2+) on the Na,K-ATPase in the cell is one of stimulation and that the inhibition reported by others is an artefact occasioned eit...

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Bibliographic Details
Published in:FEBS letters 1981-04, Vol.126 (2), p.285-288
Main Authors: Powis, D.A., Wattus, Glynis D.
Format: Article
Language:English
Subjects:
adenosinetriphosphatase
Animals
brain
Brain - enzymology
calcium
Calcium - pharmacology
Cell Membrane - enzymology
Edetic Acid - pharmacology
Enzyme Activation - drug effects
Female
Male
Rats
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase - metabolism
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Summary:In the absence of EDTA, lower (Ca super(2+)) values have a pronounced stimulatory effect on Na,K-ATPase. On this basis, it is contended that the normal effect of Ca super(2+) on the Na,K-ATPase in the cell is one of stimulation and that the inhibition reported by others is an artefact occasioned either by the use of chelating agents in the experimental medium or by the use of Ca super(2+) at levels much higher than those which would usually be encountered physiologically.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(81)80262-1