Ultrastructural changes in salivary glands after different adrenergic and cholinergic stimulations. A long-term morphological study in the rat

We have compared four different sialogogues and their degranulating effect on serous and mucous cells, and their long-term effects. From this and earlier experiments, even within the groups of alpha- and beta-adrenergic agents used, the effects varied on the serous and mucous cells. Previous studies...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 1993-03, Vol.250 (1), p.33-39
Main Authors: GEMRYD, P, LUNDQUIST, P. G, NORBERG, L
Format: Article
Language:English
Subjects:
Ancitabine - administration & dosage
Ancitabine - pharmacology
Animals
Biological and medical sciences
Carbachol - administration & dosage
Carbachol - pharmacology
Cell Degranulation - drug effects
Cell Nucleus - ultrastructure
Clonidine - administration & dosage
Clonidine - pharmacology
Cytoplasm - drug effects
Cytoplasm - ultrastructure
Cytoplasmic Granules - drug effects
Cytoplasmic Granules - ultrastructure
Desmosomes - ultrastructure
Endoplasmic Reticulum - drug effects
Endoplasmic Reticulum - ultrastructure
Ent. Stomatology
Injections, Intraperitoneal
Male
Medical sciences
Mitochondria - drug effects
Mitochondria - ultrastructure
Norepinephrine - administration & dosage
Norepinephrine - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Submandibular Gland - drug effects
Submandibular Gland - ultrastructure
Time Factors
Vacuoles - ultrastructure
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Summary:We have compared four different sialogogues and their degranulating effect on serous and mucous cells, and their long-term effects. From this and earlier experiments, even within the groups of alpha- and beta-adrenergic agents used, the effects varied on the serous and mucous cells. Previous studies have shown that cyclocytidine effectively degranulates serous cells without signs of cellular damage, while carbachol predominantly affects mucous acinar cells but gives early rise to permanent gland damage. Noradrenaline affects both serous and mucous cells, predominantly affecting serous cells with initial mitochondrial damage. Clonidine partially depletes both serous and mucous cells of their granules, producing permanent cellular damage. One month after a single injection of cyclocytidine the early findings described had disappeared. Carbachol showed permanent damage to salivary gland parenchyma, and both noradrenaline and clonidine demonstrated a long-term effect on acinar mucinous cells.
ISSN:0937-4477
1434-4726
DOI:10.1007/BF00176946