Clinical and Immunologic Responses of Silvered Leaf Monkeys (Presbytis cristatus) to Experimental Reinfection with Rickettsia tsutsugamushi

Silvered leaf monkeys (Presbytis cristatus) that had recovered from active Rickettsia tsutsugamushi infections 14 months previously became rickettsemic when inoculated with homologous, related, or unrelated strains of R. tsutsugamushi. In contrast to the results after the initial infection that prod...

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Bibliographic Details
Published in:The Journal of infectious diseases 1981-04, Vol.143 (4), p.558-561
Main Authors: Robinson, D. M., Gan, E., Chan, T. C., Huxsoll, D. L.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Antibody Specificity
Antigens
Cercopithecidae - immunology
Experimental Medicine
Fever - etiology
Fluorescent Antibody Technique
Immunity
Infections
Inoculation
Lymphatic Diseases - immunology
Medical research
Monkeys
Orientia tsutsugamushi
Orientia tsutsugamushi - immunology
Orientia tsutsugamushi - isolation & purification
Reinfection
Scrub typhus
Scrub Typhus - immunology
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Summary:Silvered leaf monkeys (Presbytis cristatus) that had recovered from active Rickettsia tsutsugamushi infections 14 months previously became rickettsemic when inoculated with homologous, related, or unrelated strains of R. tsutsugamushi. In contrast to the results after the initial infection that produced disease, no signs were observed after the subsequent infections. Most animals responded with detectable titers of antibody to the Karp antigen regardless of the inoculated strains. Strains recovered during rickettsemia usually had antigens related only to the challenge strains, but in three silvered leaf monkeys, antigens characteristic of both the original and the challenge strains were detected.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/143.4.558