Loading…
Tumor Progression Locus 2 (Tpl-2) Encodes a Protein Kinase Involved in the Progression of Rodent T-Cell Lymphomas and in T-Cell Activation
The Tpl-2 locus, cloned by provirus tagging from one of three sublines of the Moloney leukemia virus-induced rat thymoma 2769, defines a gene encoding a protein kinase associated with progression in 22.5% of the tumors. Tpl-2 is expressed primarily in spleen, thymus, liver, and lung. Provirus integr...
Saved in:
Published in: | Proceedings of the National Academy of Sciences - PNAS 1993-03, Vol.90 (6), p.2251-2255 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c544t-1b9ee6e351b706c4e15bba70726eab6e7861df84210f4491d889d92140d815703 |
---|---|
cites | |
container_end_page | 2255 |
container_issue | 6 |
container_start_page | 2251 |
container_title | Proceedings of the National Academy of Sciences - PNAS |
container_volume | 90 |
creator | Patriotis, Christos Makris, Antonios Bear, Susan E. Tsichlis, Philip N. |
description | The Tpl-2 locus, cloned by provirus tagging from one of three sublines of the Moloney leukemia virus-induced rat thymoma 2769, defines a gene encoding a protein kinase associated with progression in 22.5% of the tumors. Tpl-2 is expressed primarily in spleen, thymus, liver, and lung. Provirus integration occurs in the last intron of the gene, leading to the expression of a truncated mRNA that terminates in the proviral long terminal repeat and encodes a protein with an altered C-terminal domain. Strong evidence that this genetic change confers growth advantage to affected cell clones was provided by the finding that, during cultivation of all three sublines derived from tumor 2769, cells were selected that harbored independent provirus insertions in the Tpl-2 locus. Exposure of normal rat spleen cells to Con A induces the expression of enhanced levels of Tpl-2 within the first 60 min from the time of exposure suggesting that, in normal splenocytes, Tpl-2 may be involved in the transition from a quiescent to the G1phase of the cell cycle. |
doi_str_mv | 10.1073/pnas.90.6.2251 |
format | article |
fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_75674736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>2361504</jstor_id><sourcerecordid>2361504</sourcerecordid><originalsourceid>FETCH-LOGICAL-c544t-1b9ee6e351b706c4e15bba70726eab6e7861df84210f4491d889d92140d815703</originalsourceid><addsrcrecordid>eNqFksGL1DAUxoMo67h69aQQRBY9tL6kadKAl2VYdXFAkfEc0jbd6dAms0k7uP-Cf7WpU4dZD3oKvO_3fS8veQg9J5ASENm7ndUhlZDylNKcPEALApIknEl4iBYAVCQFo-wxehLCFgBkXsAZOhO8ILkkC_RzPfbO46_e3XgTQussXrlqDJjiN-tdl9C3-MpWrjYB64kaTGvx5zY2Nfja7l23NzWOpWFj7oW4Bn-LLjvgdbI0XYdXd_1u43odc-xvx1y_rIZ2r4foeYoeNboL5tl8nqPvH67Wy0_J6svH6-XlKqlyxoaElNIYbrKclAJ4xQzJy1ILEJQbXXIjCk7qJg5NoGFMkrooZC0pYVDHmQVk5-j9IXc3lr2pq3hJrzu1822v_Z1yulX3Fdtu1I3bK8aBs2i_mO3e3Y4mDKpvQxVH0da4MSiRc8FExv8LEs4Yz0FG8NVf4NaN3sY3UBQIFZJJEaH0AFXeheBNc7wwATVtgpo2QUlQXE2bEA0vT8c84vPXR_31rOtQ6a7x2lZtOGJMxAfM4CRmiv-jnra5-JeumrHrBvNjiOCLA7gNg_NHkmac5MCyXwqA3D8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201279497</pqid></control><display><type>article</type><title>Tumor Progression Locus 2 (Tpl-2) Encodes a Protein Kinase Involved in the Progression of Rodent T-Cell Lymphomas and in T-Cell Activation</title><source>PubMed (Medline)</source><source>JSTOR Archival Journals and Primary Sources Collection</source><creator>Patriotis, Christos ; Makris, Antonios ; Bear, Susan E. ; Tsichlis, Philip N.</creator><creatorcontrib>Patriotis, Christos ; Makris, Antonios ; Bear, Susan E. ; Tsichlis, Philip N.</creatorcontrib><description>The Tpl-2 locus, cloned by provirus tagging from one of three sublines of the Moloney leukemia virus-induced rat thymoma 2769, defines a gene encoding a protein kinase associated with progression in 22.5% of the tumors. Tpl-2 is expressed primarily in spleen, thymus, liver, and lung. Provirus integration occurs in the last intron of the gene, leading to the expression of a truncated mRNA that terminates in the proviral long terminal repeat and encodes a protein with an altered C-terminal domain. Strong evidence that this genetic change confers growth advantage to affected cell clones was provided by the finding that, during cultivation of all three sublines derived from tumor 2769, cells were selected that harbored independent provirus insertions in the Tpl-2 locus. Exposure of normal rat spleen cells to Con A induces the expression of enhanced levels of Tpl-2 within the first 60 min from the time of exposure suggesting that, in normal splenocytes, Tpl-2 may be involved in the transition from a quiescent to the G1phase of the cell cycle.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.6.2251</identifier><identifier>PMID: 7681591</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>activation ; Amino Acid Sequence ; Animal tumors. Experimental tumors ; Animals ; Base Sequence ; Biochemistry ; Biological and medical sciences ; Blotting, Northern ; Blotting, Southern ; cDNA ; Cell lines ; Cells, Cultured ; Complementary DNA ; Concanavalin A ; DNA Probes ; DNA, Neoplasm - genetics ; DNA, Neoplasm - isolation & purification ; Experimental malignant blood diseases ; gene products ; genes ; Genetic loci ; Genomics ; Liver - enzymology ; Lung - enzymology ; Lymphocyte Activation ; lymphocytes T ; Lymphoma, T-Cell - enzymology ; Lymphoma, T-Cell - genetics ; Lymphoma, T-Cell - physiopathology ; MAP Kinase Kinase Kinases ; Medical sciences ; Molecular Sequence Data ; Moloney murine leukemia virus - genetics ; nucleotide sequence ; Oligodeoxyribonucleotides ; Poly A - genetics ; Poly A - isolation & purification ; Polymerase Chain Reaction - methods ; predictions ; protein kinase ; Protein Kinases - genetics ; Protein Kinases - metabolism ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Proteins ; Proto-Oncogene Proteins ; Proviruses ; Rats ; Rats, Inbred F344 ; Restriction Mapping ; RNA ; RNA - genetics ; RNA - isolation & purification ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Spleen - enzymology ; Spleen - immunology ; Spleen cells ; T-Lymphocytes - immunology ; T-Lymphocytes - physiology ; Tumor cell line ; Tumor Cells, Cultured ; tumor progression locus 2 locus ; Tumors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (6), p.2251-2255</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1993 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Mar 15, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-1b9ee6e351b706c4e15bba70726eab6e7861df84210f4491d889d92140d815703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/6.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2361504$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2361504$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4721030$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7681591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patriotis, Christos</creatorcontrib><creatorcontrib>Makris, Antonios</creatorcontrib><creatorcontrib>Bear, Susan E.</creatorcontrib><creatorcontrib>Tsichlis, Philip N.</creatorcontrib><title>Tumor Progression Locus 2 (Tpl-2) Encodes a Protein Kinase Involved in the Progression of Rodent T-Cell Lymphomas and in T-Cell Activation</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The Tpl-2 locus, cloned by provirus tagging from one of three sublines of the Moloney leukemia virus-induced rat thymoma 2769, defines a gene encoding a protein kinase associated with progression in 22.5% of the tumors. Tpl-2 is expressed primarily in spleen, thymus, liver, and lung. Provirus integration occurs in the last intron of the gene, leading to the expression of a truncated mRNA that terminates in the proviral long terminal repeat and encodes a protein with an altered C-terminal domain. Strong evidence that this genetic change confers growth advantage to affected cell clones was provided by the finding that, during cultivation of all three sublines derived from tumor 2769, cells were selected that harbored independent provirus insertions in the Tpl-2 locus. Exposure of normal rat spleen cells to Con A induces the expression of enhanced levels of Tpl-2 within the first 60 min from the time of exposure suggesting that, in normal splenocytes, Tpl-2 may be involved in the transition from a quiescent to the G1phase of the cell cycle.</description><subject>activation</subject><subject>Amino Acid Sequence</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Blotting, Southern</subject><subject>cDNA</subject><subject>Cell lines</subject><subject>Cells, Cultured</subject><subject>Complementary DNA</subject><subject>Concanavalin A</subject><subject>DNA Probes</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>Experimental malignant blood diseases</subject><subject>gene products</subject><subject>genes</subject><subject>Genetic loci</subject><subject>Genomics</subject><subject>Liver - enzymology</subject><subject>Lung - enzymology</subject><subject>Lymphocyte Activation</subject><subject>lymphocytes T</subject><subject>Lymphoma, T-Cell - enzymology</subject><subject>Lymphoma, T-Cell - genetics</subject><subject>Lymphoma, T-Cell - physiopathology</subject><subject>MAP Kinase Kinase Kinases</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Moloney murine leukemia virus - genetics</subject><subject>nucleotide sequence</subject><subject>Oligodeoxyribonucleotides</subject><subject>Poly A - genetics</subject><subject>Poly A - isolation & purification</subject><subject>Polymerase Chain Reaction - methods</subject><subject>predictions</subject><subject>protein kinase</subject><subject>Protein Kinases - genetics</subject><subject>Protein Kinases - metabolism</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins</subject><subject>Proviruses</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Restriction Mapping</subject><subject>RNA</subject><subject>RNA - genetics</subject><subject>RNA - isolation & purification</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Spleen - enzymology</subject><subject>Spleen - immunology</subject><subject>Spleen cells</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><subject>Tumor cell line</subject><subject>Tumor Cells, Cultured</subject><subject>tumor progression locus 2 locus</subject><subject>Tumors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqFksGL1DAUxoMo67h69aQQRBY9tL6kadKAl2VYdXFAkfEc0jbd6dAms0k7uP-Cf7WpU4dZD3oKvO_3fS8veQg9J5ASENm7ndUhlZDylNKcPEALApIknEl4iBYAVCQFo-wxehLCFgBkXsAZOhO8ILkkC_RzPfbO46_e3XgTQussXrlqDJjiN-tdl9C3-MpWrjYB64kaTGvx5zY2Nfja7l23NzWOpWFj7oW4Bn-LLjvgdbI0XYdXd_1u43odc-xvx1y_rIZ2r4foeYoeNboL5tl8nqPvH67Wy0_J6svH6-XlKqlyxoaElNIYbrKclAJ4xQzJy1ILEJQbXXIjCk7qJg5NoGFMkrooZC0pYVDHmQVk5-j9IXc3lr2pq3hJrzu1822v_Z1yulX3Fdtu1I3bK8aBs2i_mO3e3Y4mDKpvQxVH0da4MSiRc8FExv8LEs4Yz0FG8NVf4NaN3sY3UBQIFZJJEaH0AFXeheBNc7wwATVtgpo2QUlQXE2bEA0vT8c84vPXR_31rOtQ6a7x2lZtOGJMxAfM4CRmiv-jnra5-JeumrHrBvNjiOCLA7gNg_NHkmac5MCyXwqA3D8</recordid><startdate>19930315</startdate><enddate>19930315</enddate><creator>Patriotis, Christos</creator><creator>Makris, Antonios</creator><creator>Bear, Susan E.</creator><creator>Tsichlis, Philip N.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>M81</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930315</creationdate><title>Tumor Progression Locus 2 (Tpl-2) Encodes a Protein Kinase Involved in the Progression of Rodent T-Cell Lymphomas and in T-Cell Activation</title><author>Patriotis, Christos ; Makris, Antonios ; Bear, Susan E. ; Tsichlis, Philip N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-1b9ee6e351b706c4e15bba70726eab6e7861df84210f4491d889d92140d815703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>activation</topic><topic>Amino Acid Sequence</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Blotting, Southern</topic><topic>cDNA</topic><topic>Cell lines</topic><topic>Cells, Cultured</topic><topic>Complementary DNA</topic><topic>Concanavalin A</topic><topic>DNA Probes</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>Experimental malignant blood diseases</topic><topic>gene products</topic><topic>genes</topic><topic>Genetic loci</topic><topic>Genomics</topic><topic>Liver - enzymology</topic><topic>Lung - enzymology</topic><topic>Lymphocyte Activation</topic><topic>lymphocytes T</topic><topic>Lymphoma, T-Cell - enzymology</topic><topic>Lymphoma, T-Cell - genetics</topic><topic>Lymphoma, T-Cell - physiopathology</topic><topic>MAP Kinase Kinase Kinases</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Moloney murine leukemia virus - genetics</topic><topic>nucleotide sequence</topic><topic>Oligodeoxyribonucleotides</topic><topic>Poly A - genetics</topic><topic>Poly A - isolation & purification</topic><topic>Polymerase Chain Reaction - methods</topic><topic>predictions</topic><topic>protein kinase</topic><topic>Protein Kinases - genetics</topic><topic>Protein Kinases - metabolism</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins</topic><topic>Proviruses</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Restriction Mapping</topic><topic>RNA</topic><topic>RNA - genetics</topic><topic>RNA - isolation & purification</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Spleen - enzymology</topic><topic>Spleen - immunology</topic><topic>Spleen cells</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><topic>Tumor cell line</topic><topic>Tumor Cells, Cultured</topic><topic>tumor progression locus 2 locus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patriotis, Christos</creatorcontrib><creatorcontrib>Makris, Antonios</creatorcontrib><creatorcontrib>Bear, Susan E.</creatorcontrib><creatorcontrib>Tsichlis, Philip N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Biochemistry Abstracts 3</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patriotis, Christos</au><au>Makris, Antonios</au><au>Bear, Susan E.</au><au>Tsichlis, Philip N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor Progression Locus 2 (Tpl-2) Encodes a Protein Kinase Involved in the Progression of Rodent T-Cell Lymphomas and in T-Cell Activation</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1993-03-15</date><risdate>1993</risdate><volume>90</volume><issue>6</issue><spage>2251</spage><epage>2255</epage><pages>2251-2255</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The Tpl-2 locus, cloned by provirus tagging from one of three sublines of the Moloney leukemia virus-induced rat thymoma 2769, defines a gene encoding a protein kinase associated with progression in 22.5% of the tumors. Tpl-2 is expressed primarily in spleen, thymus, liver, and lung. Provirus integration occurs in the last intron of the gene, leading to the expression of a truncated mRNA that terminates in the proviral long terminal repeat and encodes a protein with an altered C-terminal domain. Strong evidence that this genetic change confers growth advantage to affected cell clones was provided by the finding that, during cultivation of all three sublines derived from tumor 2769, cells were selected that harbored independent provirus insertions in the Tpl-2 locus. Exposure of normal rat spleen cells to Con A induces the expression of enhanced levels of Tpl-2 within the first 60 min from the time of exposure suggesting that, in normal splenocytes, Tpl-2 may be involved in the transition from a quiescent to the G1phase of the cell cycle.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>7681591</pmid><doi>10.1073/pnas.90.6.2251</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0027-8424 |
ispartof | Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (6), p.2251-2255 |
issn | 0027-8424 1091-6490 |
language | eng |
recordid | cdi_proquest_miscellaneous_75674736 |
source | PubMed (Medline); JSTOR Archival Journals and Primary Sources Collection |
subjects | activation Amino Acid Sequence Animal tumors. Experimental tumors Animals Base Sequence Biochemistry Biological and medical sciences Blotting, Northern Blotting, Southern cDNA Cell lines Cells, Cultured Complementary DNA Concanavalin A DNA Probes DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Experimental malignant blood diseases gene products genes Genetic loci Genomics Liver - enzymology Lung - enzymology Lymphocyte Activation lymphocytes T Lymphoma, T-Cell - enzymology Lymphoma, T-Cell - genetics Lymphoma, T-Cell - physiopathology MAP Kinase Kinase Kinases Medical sciences Molecular Sequence Data Moloney murine leukemia virus - genetics nucleotide sequence Oligodeoxyribonucleotides Poly A - genetics Poly A - isolation & purification Polymerase Chain Reaction - methods predictions protein kinase Protein Kinases - genetics Protein Kinases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins Proviruses Rats Rats, Inbred F344 Restriction Mapping RNA RNA - genetics RNA - isolation & purification RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Spleen - enzymology Spleen - immunology Spleen cells T-Lymphocytes - immunology T-Lymphocytes - physiology Tumor cell line Tumor Cells, Cultured tumor progression locus 2 locus Tumors |
title | Tumor Progression Locus 2 (Tpl-2) Encodes a Protein Kinase Involved in the Progression of Rodent T-Cell Lymphomas and in T-Cell Activation |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A45%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tumor%20Progression%20Locus%202%20(Tpl-2)%20Encodes%20a%20Protein%20Kinase%20Involved%20in%20the%20Progression%20of%20Rodent%20T-Cell%20Lymphomas%20and%20in%20T-Cell%20Activation&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Patriotis,%20Christos&rft.date=1993-03-15&rft.volume=90&rft.issue=6&rft.spage=2251&rft.epage=2255&rft.pages=2251-2255&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.90.6.2251&rft_dat=%3Cjstor_proqu%3E2361504%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c544t-1b9ee6e351b706c4e15bba70726eab6e7861df84210f4491d889d92140d815703%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=201279497&rft_id=info:pmid/7681591&rft_jstor_id=2361504&rfr_iscdi=true |