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ESR-measurement of oxygen radicals in vivo after renal ischaemia in the rabbit. Effects of pre-treatment with superoxide dismutase and heparin

The effects of intracellular and extraceIlular superoxide dismutase and heparin administration on oxygen radical formation after ischaemia in the rabbit kidney were studied. Radicals were measured with ESR and spin trapping. At reperfusion after 60 min of renal ischaemia there was a significant incr...

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Published in:	Acta physiologica Scandinavica 1993-03, Vol.147 (3), p.263-270
Main Authors:	NILSSON, U. A., HARALDSSON, G., BRATELL, S., SORENSEN, V., AKERLUND, S., PETTERSSON, S., SCHERSTEN, T., JONSSON, O.
Format:	Article
Language:	English
Subjects:	Animals EC superoxide dismutase Electron Spin Resonance Spectroscopy ESR Free Radicals - metabolism heparin Heparin - pharmacology IC superoxide dismutase ischaemia Ischemia - metabolism kidney OXANO OXANOH Oxazoles Oxygen Consumption - drug effects Oxygen Consumption - physiology Rabbits Renal Circulation - drug effects Renal Circulation - physiology Reperfusion spin trap Superoxide Dismutase - pharmacology
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container_title	Acta physiologica Scandinavica
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creator	NILSSON, U. A. HARALDSSON, G. BRATELL, S. SORENSEN, V. AKERLUND, S. PETTERSSON, S. SCHERSTEN, T. JONSSON, O.
description	The effects of intracellular and extraceIlular superoxide dismutase and heparin administration on oxygen radical formation after ischaemia in the rabbit kidney were studied. Radicals were measured with ESR and spin trapping. At reperfusion after 60 min of renal ischaemia there was a significant increase in the production of free radicals in the venous effluent from the kidney. Administration of either intracellular superoxide dismutase or extracellular superoxide dismutase before ischaemia and before reperfusion prevented approximately 85 % of the radical formation seen in the untreated control group. Administration of heparin 5 min before recirculation resulted in a 65% decrease in radical production compared to the control group.
doi_str_mv	10.1111/j.1748-1716.1993.tb09498.x
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Administration of either intracellular superoxide dismutase or extracellular superoxide dismutase before ischaemia and before reperfusion prevented approximately 85 % of the radical formation seen in the untreated control group. 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A.</creatorcontrib><creatorcontrib>HARALDSSON, G.</creatorcontrib><creatorcontrib>BRATELL, S.</creatorcontrib><creatorcontrib>SORENSEN, V.</creatorcontrib><creatorcontrib>AKERLUND, S.</creatorcontrib><creatorcontrib>PETTERSSON, S.</creatorcontrib><creatorcontrib>SCHERSTEN, T.</creatorcontrib><creatorcontrib>JONSSON, O.</creatorcontrib><title>ESR-measurement of oxygen radicals in vivo after renal ischaemia in the rabbit. Effects of pre-treatment with superoxide dismutase and heparin</title><title>Acta physiologica Scandinavica</title><addtitle>Acta Physiol Scand</addtitle><description>The effects of intracellular and extraceIlular superoxide dismutase and heparin administration on oxygen radical formation after ischaemia in the rabbit kidney were studied. Radicals were measured with ESR and spin trapping. At reperfusion after 60 min of renal ischaemia there was a significant increase in the production of free radicals in the venous effluent from the kidney. Administration of either intracellular superoxide dismutase or extracellular superoxide dismutase before ischaemia and before reperfusion prevented approximately 85 % of the radical formation seen in the untreated control group. Administration of heparin 5 min before recirculation resulted in a 65% decrease in radical production compared to the control group.</description><subject>Animals</subject><subject>EC superoxide dismutase</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>ESR</subject><subject>Free Radicals - metabolism</subject><subject>heparin</subject><subject>Heparin - pharmacology</subject><subject>IC superoxide dismutase</subject><subject>ischaemia</subject><subject>Ischemia - metabolism</subject><subject>kidney</subject><subject>OXANO</subject><subject>OXANOH</subject><subject>Oxazoles</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen Consumption - physiology</subject><subject>Rabbits</subject><subject>Renal Circulation - drug effects</subject><subject>Renal Circulation - physiology</subject><subject>Reperfusion</subject><subject>spin trap</subject><subject>Superoxide Dismutase - pharmacology</subject><issn>0001-6772</issn><issn>1365-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqVkc9u1DAQxiMEKkvhEZAsDtySxnZiO1zQUi0tUgWIgpab5cRj1kv-YTtt9iX6zDjsqnfmYo2-b34jz5ckb3Ce4VgX-wzzQqSYY5bhqqJZqPOqqEQ2P0lWmLIyJTn--TRZ5XmOU8Y5eZ688H4fWyoIOUvOBBWsIOUqedjcfks7UH5y0EEf0GDQMB9-QY-c0rZRrUe2R3f2bkDKBHDIQa9aZH2zU9BZtahhB9Fd1zZkaGMMNMEvnNFBGhyo8A98b8MO-WkEN8xWA9LWd1NQHpDqNdrBqJztXybPTFwJr07vefLj4-b75XV68-Xq0-X6Jm0ooTTFJSkqonVT00rFK5S10VyYRjCOywbnwghRANZlbjDTmtYsx1QYU3AmFFY1PU_eHrmjG_5M4IPs4o-gbVUPw-QlLxkXgpTR-O5obNzgvQMjR2c75Q4S53IJQ-7lEoZcwpBLGPIUhpzj8OvTlqnuQD-Onq4f9fdH_d62cPgPslx_vV4TRiMhPRKsDzA_EpT7LRmnvJTbz1dSbG-LD8VWyIr-BYCIq6I</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>NILSSON, U. 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At reperfusion after 60 min of renal ischaemia there was a significant increase in the production of free radicals in the venous effluent from the kidney. Administration of either intracellular superoxide dismutase or extracellular superoxide dismutase before ischaemia and before reperfusion prevented approximately 85 % of the radical formation seen in the untreated control group. Administration of heparin 5 min before recirculation resulted in a 65% decrease in radical production compared to the control group.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8386425</pmid><doi>10.1111/j.1748-1716.1993.tb09498.x</doi><tpages>8</tpages></addata></record>
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subjects	Animals EC superoxide dismutase Electron Spin Resonance Spectroscopy ESR Free Radicals - metabolism heparin Heparin - pharmacology IC superoxide dismutase ischaemia Ischemia - metabolism kidney OXANO OXANOH Oxazoles Oxygen Consumption - drug effects Oxygen Consumption - physiology Rabbits Renal Circulation - drug effects Renal Circulation - physiology Reperfusion spin trap Superoxide Dismutase - pharmacology
title	ESR-measurement of oxygen radicals in vivo after renal ischaemia in the rabbit. Effects of pre-treatment with superoxide dismutase and heparin
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