Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Here we describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depen...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-10, Vol.46 (40), p.7516-7518
Main Authors: Bresee, Jamee, Maier, Keith E, Melander, Christian, Feldheim, Daniel L
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Escherichia coli - drug effects
Escherichia coli - growth & development
Escherichia coli Infections - drug therapy
Gold - chemistry
Ligands
Metal Nanoparticles - chemistry
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
Sulfhydryl Compounds - chemistry
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Summary:Here we describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depend upon the combination of thiols assembled onto the nanoparticles. The most active conjugate displayed 99.9% growth inhibition at 0.5 μM.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc02663h