Metabolic syndrome and chronic kidney disease

The prevalence of metabolic syndrome (MetS) is increasing worldwide in both developing and developed countries. Experimental and clinical studies have revealed that MetS plays an important role in the development of chronic kidney disease (CKD), which leads to end‐stage renal disease. Emerging evide...

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Bibliographic Details
Published in:Journal of diabetes 2009-12, Vol.1 (4), p.236-245
Main Authors: RUAN, Xiongzhong, GUAN, Youfei
Format: Article
Language:English
Subjects:
Adult
Albuminuria - etiology
chronic renal disease
Diabetes Mellitus, Type 2 - complications
Diabetic Nephropathies - complications
Glomerular Filtration Rate
Glucose - metabolism
Humans
Inflammation - etiology
Insulin - physiology
Insulin Resistance
Kidney Diseases - complications
Kidney Failure, Chronic - complications
metabolic syndrome
Metabolic Syndrome - classification
Metabolic Syndrome - complications
Metabolic Syndrome - physiopathology
Oxidative Stress
Renal Circulation - physiology
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Description
Summary:The prevalence of metabolic syndrome (MetS) is increasing worldwide in both developing and developed countries. Experimental and clinical studies have revealed that MetS plays an important role in the development of chronic kidney disease (CKD), which leads to end‐stage renal disease. Emerging evidence also suggests that CKD may actually cause MetS since the kidney is an important organ of glucose and lipid homeostasis. Although multiple mechanisms have been shown to be involved in the pathogenesis of MetS, insulin resistance appears to be a central pathophysiological factor contributing to MetS. In this review we will discuss the association of MetS with insulin resistance and CKD, and the renal pathophysiological changes associated with MetS.
ISSN:1753-0393
1753-0407
DOI:10.1111/j.1753-0407.2009.00042.x