Biopterin Cofactor Biosynthesis: Independent Regulation of GTP Cyclohydrolase in Adrenal Medulla and Cortex

Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectivel...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-07, Vol.213 (4505), p.349-350
Main Authors: Viveros, O. Humberto, Lee, Ching-Lun, Abou-Donia, Martha M., Nixon, Jon C., Nichol, Charles A.
Format: Article
Language:English
Subjects:
Adrenal cortex
Adrenal Cortex - drug effects
Adrenal Cortex - enzymology
Adrenal Glands - innervation
Adrenal medulla
Adrenal Medulla - drug effects
Adrenal Medulla - enzymology
Aminohydrolases - metabolism
Animals
Biochemistry
Biopterins - biosynthesis
Cycloheximide - pharmacology
Denervation
Enzyme activity
Enzymes
Gene induction
GTP Cyclohydrolase - metabolism
Hypophysectomy
Insulin
Insulin - pharmacology
Kinetics
Male
Organ Specificity
Physiological regulation
Pteridines - biosynthesis
Rats
Reserpine - pharmacology
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Summary:Guanosine triphosphate cyclohydrolase, the enzyme that is apparently rate-limiting in biopterin biosynthesis, is increased in adrenal cortex and medulla of rats treated with insulin or reserpine. Denervation and hypophysectomy block the increase in medullary and cortical enzyme activity, respectively, whereas cycloheximide prevents the increase in both tissues. These results provide evidence for induction and regulation of guanosine triphosphate cyclohydrolase.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7017928