5-N-ACETYLARDEEMIN, A NOVEL HETEROCYCLIC COMPOUND WHICH REVERSES MULTIPLE DRUG RESISTANCE IN TUMOR CELLS: II. ISOLATION AND ELUCIDATION OF THE STRUCTURE OF 5-N-ACETYLARDEEMIN AND TWO CONGENERS

A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were...

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Bibliographic Details
Published in:Journal of antibiotics 1993/03/25, Vol.46(3), pp.380-386
Main Authors: HOCHLOWSKI, JILL E., MULLALLY, MARK M., SPANTON, STEPHEN G., WHITTERN, DAVID N., HILL, PRESTON, MCALPINE, JAMES B.
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Aspergillus - chemistry
Biological and medical sciences
Chemotherapic agents
Drug Resistance, Microbial
Fundamental and applied biological sciences. Psychology
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - isolation & purification
Heterocyclic Compounds - pharmacology
Humans
Magnetic Resonance Spectroscopy
Microbiology
Pyrimidinones - chemistry
Pyrimidinones - isolation & purification
Pyrimidinones - pharmacology
Tumor Cells, Cultured - drug effects
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Summary:A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were determined employing 1-D and 2-D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. The structure of 5-N-acetylardeemin was confirmed by single crystal X-ray diffraction. These compounds are most closely structurally related to asnerlicin E1)
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.380