Stimulation of Glucose Incorporation and Amino Acid Transport by Insulin and an Insulin-Like Growth Factor in Fibroblasts with Defective Insulin Receptors Cultured from a Patient with Leprechaunism

Fibroblasts cultured from an infant with leprechaunism and insulin resistance have been reported to exhibit a profound, selective defect in insulin binding. We now examine the effect of this defect on two acute metabolic actions of insulin thought to be mediated by the insulin receptor, glucose inco...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1981-04, Vol.78 (4), p.2554-2558
Main Authors: Knight, Alfred B., Rechler, Matthew M., Romanus, Joyce A., Van Obberghen-Schilling, Ellen E., Nissley, S. Peter
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Beta cells
Cells, Cultured
Corporations
Cultured cells
Donohue syndrome
Dose response relationship
Dwarfism - metabolism
Face
Fibroblasts
Fibroblasts - metabolism
Glucose - metabolism
Growth Substances - pharmacology
Humans
Insulin
Insulin - pharmacology
Insulin Resistance
Insulin-Like Growth Factor II
Male
Metabolism
Peptides - pharmacology
Receptors
Somatomedins
Syndrome
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Summary:Fibroblasts cultured from an infant with leprechaunism and insulin resistance have been reported to exhibit a profound, selective defect in insulin binding. We now examine the effect of this defect on two acute metabolic actions of insulin thought to be mediated by the insulin receptor, glucose incorporation and N-methyl-α -aminoisobutyric acid (Me-AiBu) uptake. In the patient's fibroblasts, maximal insulin-stimulated glucose incorporation was
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.78.4.2554